PMID- 24693507
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140402
LR  - 20211021
IS  - 2251-7006 (Print)
IS  - 2251-7014 (Electronic)
IS  - 2251-7006 (Linking)
VI  - 5
IP  - 5
DP  - 2013 Nov
TI  - Influence of Donors' and Recipients' HLA Typing on Renal Function Immediately 
      After Kidney Transplantation.
PG  - 988-91
LID - 10.5812/numonthly.12328 [doi]
AB  - BACKGROUND: The human leukocyte antigen (HLA) system is widely used as a strategy 
      in the search for the etiology of renal function impairment. OBJECTIVES: This 
      study was carried out to detect the most common HLA alleles' distribution in 
      kidney transplant in both donors and recipients, and clarify the association 
      between HLA alleles and renal dysfunction immediately after transplantation. 
      PATIENTS AND METHODS: HLA-class I and II alleles typing by PCR-SSOP was performed 
      on a total of 874 recipients aged 40.7 +/- 13.8 (male/female: 562/279) and 874 
      donor aged 27.5 +/- 5.3 (male/female: 683/110), between 2006 and 2009 in 
      Baqiyatallah, hospital, Tehran, Iran. In this retrospective, cross sectional 
      study, data were obtained from personal files. Donors aged 40.9 +/- 13.6 years and 
      male/female 390/195, while recipients had a mean age 27.5 +/- 5.3 and male/female 
      523/83. Renal dysfunction defined as acute rejection, acute tubular necrosis and 
      Delay graft function. RESULTS: In this study common alleles at each of the loci 
      for the human leukocyte antigen (HLA) class I (A, B, and C) and class II (DR and 
      DQ) were A2 (n = 186, 33.8%), Bw6 (n = 196, 47.5%), Cw4 (n = 164, 39.7%), DR52 (n 
      = 161, 29.6%), DQ3 (n = 101, 40.1%) for donors; while A2 (n = 200, 34%), BW6 (n = 
      235, 38.8%), Cw6 (n = 23, 15.2%), DR511 (n = 174, 30.4%), DQ1 (n = 99, 46.3%) for 
      recipients. We detected a total of 139 case of renal dysfunction among RTRs. By 
      the way only cold ischemic time (P = 0.03) and severe anemia (P = 0.000) were 
      significantly associated with renal dysfunction early post kidney 
      transplantation. CONCLUSIONS: We can predict high risk groups before kidney 
      transplantation and try to establish a screening program for the detection of 
      genetic susceptibility to renal function impairment. HLA typing of the donors and 
      recipients might influence the development of new treatment strategy.
FAU - Rostami, Zohreh
AU  - Rostami Z
AD  - Nephrology and Urology Research Center, Baqiyatallah University of Medical 
      Sciences, Tehran, IR Iran.
FAU - Shafighiee, Nasrollah
AU  - Shafighiee N
AD  - Nephrology and Urology Research Center, Baqiyatallah University of Medical 
      Sciences, Tehran, IR Iran.
FAU - Baghersad, Mohammad Mahdi
AU  - Baghersad MM
AD  - Nephrology and Urology Research Center, Baqiyatallah University of Medical 
      Sciences, Tehran, IR Iran.
FAU - Einollahi, Behzad
AU  - Einollahi B
AD  - Nephrology and Urology Research Center, Baqiyatallah University of Medical 
      Sciences, Tehran, IR Iran.
LA  - eng
PT  - Journal Article
DEP - 20131113
PL  - Netherlands
TA  - Nephrourol Mon
JT  - Nephro-urology monthly
JID - 101578609
PMC - PMC3955292
OTO - NOTNLM
OT  - Delayed Graft Function
OT  - Histocompatibility Testing
OT  - Kidney Transplantation
EDAT- 2014/04/03 06:00
MHDA- 2014/04/03 06:01
PMCR- 2013/11/01
CRDT- 2014/04/03 06:00
PHST- 2013/05/20 00:00 [received]
PHST- 2013/06/28 00:00 [accepted]
PHST- 2014/04/03 06:00 [entrez]
PHST- 2014/04/03 06:00 [pubmed]
PHST- 2014/04/03 06:01 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - 10.5812/numonthly.12328 [doi]
PST - ppublish
SO  - Nephrourol Mon. 2013 Nov;5(5):988-91. doi: 10.5812/numonthly.12328. Epub 2013 Nov 
      13.