PMID- 24695086
OWN - NLM
STAT- MEDLINE
DCOM- 20141209
LR  - 20140428
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 568
DP  - 2014 May 7
TI  - Differential role of temporoparietal junction and medial prefrontal cortex in 
      causal inference in autism: an independent component analysis.
PG  - 50-5
LID - S0304-3940(14)00250-X [pii]
LID - 10.1016/j.neulet.2014.03.051 [doi]
AB  - Neuroimaging studies have consistently identified a network of brain regions 
      responsible for making inferences of others' mental states. This network includes 
      the medial prefrontal cortex (MPFC), posterior superior temporal sulcus (pSTS) at 
      the temporoparietal junction (TPJ), and temporal poles. Although TPJ and MPFC are 
      key nodes of the Theory of Mind (ToM) network, their relative functional roles 
      are still debated. This study sought to examine the contribution of these regions 
      in causal attribution and to explore the nature of the ToM network in people with 
      autism spectrum disorders (ASD). Participants watched a series of comic strip 
      vignettes in the MRI scanner, and identified the most logical ending to each 
      vignette, which sometimes required intentional causal attribution. Independent 
      component analysis was done to isolate temporally correlated brain networks. The 
      functional networks for intentional causality included the TPJ and MPFC, with an 
      increased contribution of TPJ. There was also a significant group difference in 
      the TPJ, with reduced response in participants with ASD. These results suggest an 
      increased role of TPJ in intentional causality. In addition, the reduced response 
      in ASD in TPJ may reflect their difficulties in social cognition.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Murdaugh, Donna L
AU  - Murdaugh DL
AD  - Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
FAU - Nadendla, Kavita D
AU  - Nadendla KD
AD  - Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
FAU - Kana, Rajesh K
AU  - Kana RK
AD  - Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, 
      USA. Electronic address: rkana@uab.edu.
LA  - eng
PT  - Journal Article
DEP - 20140330
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
SB  - IM
MH  - Adult
MH  - Autistic Disorder/*physiopathology/psychology
MH  - Case-Control Studies
MH  - Data Interpretation, Statistical
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Parietal Lobe/*physiopathology
MH  - Photic Stimulation
MH  - Prefrontal Cortex/*physiopathology
MH  - Probability
MH  - Temporal Lobe/*physiopathology
MH  - Theory of Mind
MH  - Young Adult
OTO - NOTNLM
OT  - Autism
OT  - Functional connectivity
OT  - Independent component analysis
OT  - Theory of Mind
OT  - fMRI
EDAT- 2014/04/04 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/04/04 06:00
PHST- 2014/02/18 00:00 [received]
PHST- 2014/03/18 00:00 [revised]
PHST- 2014/03/21 00:00 [accepted]
PHST- 2014/04/04 06:00 [entrez]
PHST- 2014/04/04 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0304-3940(14)00250-X [pii]
AID - 10.1016/j.neulet.2014.03.051 [doi]
PST - ppublish
SO  - Neurosci Lett. 2014 May 7;568:50-5. doi: 10.1016/j.neulet.2014.03.051. Epub 2014 
      Mar 30.