PMID- 24696780
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140403
LR  - 20240324
IS  - 2090-0422 (Print)
IS  - 2090-0430 (Electronic)
IS  - 2090-0430 (Linking)
VI  - 2014
DP  - 2014
TI  - Differential immunotoxicity induced by two different windows of developmental 
      trichloroethylene exposure.
PG  - 982073
LID - 10.1155/2014/982073 [doi]
LID - 982073
AB  - Developmental exposure to environmental toxicants may induce immune system 
      alterations that contribute to adult stage autoimmune disease. We have shown that 
      continuous exposure of MRL+/+ mice to trichloroethylene (TCE) from gestational 
      day (GD) 0 to postnatal day (PND) 49 alters several aspects of CD4(+) T cell 
      function. This window of exposure corresponds to conception-adolescence/young 
      adulthood in humans. More narrowly defining the window of TCE developmental 
      exposure causes immunotoxicity that would establish the stage at which avoidance 
      and/or intervention would be most effective. The current study divided continuous 
      TCE exposure into two separate windows, namely, gestation only (GD0 to birth 
      (PND0)) and early-life only (PND0-PND49). The mice were examined for specific 
      alterations in CD4(+) T cell function at PND49. One potentially long-lasting 
      effect of developmental exposure, alterations in retrotransposon expression 
      indicative of epigenetic alterations, was found in peripheral CD4(+) T cells from 
      both sets of developmentally exposed mice. Interestingly, certain other effects, 
      such as alterations in thymus cellularity, were only found in mice exposed to TCE 
      during gestation. In contrast, expansion of memory/activation cell subset of 
      peripheral CD4(+) T cells were only found in mice exposed to TCE during early 
      life. Different windows of developmental TCE exposure can have different 
      functional consequences.
FAU - Gilbert, Kathleen M
AU  - Gilbert KM
AD  - University of Arkansas for Medical Sciences, Arkansas Children's Hospital 
      Research Institute, 13 Children's Way, Little Rock, AR 72202, USA.
FAU - Woodruff, William
AU  - Woodruff W
AD  - University of Arkansas for Medical Sciences, Arkansas Children's Hospital 
      Research Institute, 13 Children's Way, Little Rock, AR 72202, USA.
FAU - Blossom, Sarah J
AU  - Blossom SJ
AD  - University of Arkansas for Medical Sciences, Arkansas Children's Hospital 
      Research Institute, 13 Children's Way, Little Rock, AR 72202, USA.
LA  - eng
GR  - R01 ES017286/ES/NIEHS NIH HHS/United States
GR  - R01 ES021484/ES/NIEHS NIH HHS/United States
GR  - R21 ES017311/ES/NIEHS NIH HHS/United States
GR  - UL1 RR029884/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20140220
PL  - United States
TA  - Autoimmune Dis
JT  - Autoimmune diseases
JID - 101546750
PMC - PMC3950550
EDAT- 2014/04/04 06:00
MHDA- 2014/04/04 06:01
PMCR- 2014/02/20
CRDT- 2014/04/04 06:00
PHST- 2013/10/01 00:00 [received]
PHST- 2013/11/19 00:00 [revised]
PHST- 2013/11/20 00:00 [accepted]
PHST- 2014/04/04 06:00 [entrez]
PHST- 2014/04/04 06:00 [pubmed]
PHST- 2014/04/04 06:01 [medline]
PHST- 2014/02/20 00:00 [pmc-release]
AID - 10.1155/2014/982073 [doi]
PST - ppublish
SO  - Autoimmune Dis. 2014;2014:982073. doi: 10.1155/2014/982073. Epub 2014 Feb 20.