PMID- 24697292
OWN - NLM
STAT- MEDLINE
DCOM- 20150727
LR  - 20141127
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 53
IP  - 12
DP  - 2014 Dec
TI  - Allelic variation in HLA-DRB1* loci in Syrian pemphigus vulgaris patients.
PG  - 1460-3
LID - 10.1111/ijd.12184 [doi]
AB  - BACKGROUND: Pemphigus vulgaris (PV) is known to be strongly associated with 
      particular alleles of the human leukocyte antigen (HLA)-DRB1* loci. However, to 
      date, the association of HLA with pemphigus has not been studied in a Syrian 
      population. OBJECTIVES: We aimed to study HLA-DRB1* loci variation in Syrian PV 
      patients. METHODS: We used a sequence-specific primer polymerase chain reaction 
      method to define the allele type of the DRB1* loci in 91 patients with PV and 270 
      healthy control subjects. RESULTS: We noticed an increased frequency of 
      HLA-DRB1*04 and DRB1*14 alleles in patients with PV compared with healthy control 
      subjects (67.0% vs. 26.3%; odds ratio [OR] = 5.7, corrected P < 0.0001 for 
      DRB1*04; 54.9% vs. 11.0%; OR = 9.5, corrected P < 0.0001 for DRB1*14). Among 
      DRB1*04-positive PV patients, the DRB1*402 subtype was markedly increased 
      compared with DRB1*04-positive healthy controls (84.3% vs. 26.7%; corrected P = 
      0.002), whereas the DRB1*0403 variant was represented more commonly in 
      DRB1*04-positive healthy individuals than in DRB1*04-positive PV patients (45.0% 
      vs. 1.6%; corrected P < 0.0001). In addition, the frequency of DRB1*11 was 
      significantly decreased in PV patients compared with healthy controls (19.7% vs. 
      50.4%; OR = 0.25, corrected P < 0.0001). CONCLUSIONS: The occurrence of PV is 
      positively associated with HLA-DRB1*14 and HLA-DRB1*0402 but negatively 
      associated with HLA-DRB1*11 in the Syrian population.
CI  - (c) 2014 The International Society of Dermatology.
FAU - Harfouch, Elham
AU  - Harfouch E
AD  - Laboratory for Research and Genetic Consultation, Faculty of Medicine, University 
      of Damascus, Damascus, Syria.
FAU - Daoud, Saleh
AU  - Daoud S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140402
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Female
MH  - Genetic Variation
MH  - Genotype
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pemphigus/epidemiology/*genetics
MH  - Seroepidemiologic Studies
MH  - Syria/epidemiology
MH  - Young Adult
EDAT- 2014/04/05 06:00
MHDA- 2015/07/28 06:00
CRDT- 2014/04/05 06:00
PHST- 2014/04/05 06:00 [entrez]
PHST- 2014/04/05 06:00 [pubmed]
PHST- 2015/07/28 06:00 [medline]
AID - 10.1111/ijd.12184 [doi]
PST - ppublish
SO  - Int J Dermatol. 2014 Dec;53(12):1460-3. doi: 10.1111/ijd.12184. Epub 2014 Apr 2.