PMID- 24697759
OWN - NLM
STAT- MEDLINE
DCOM- 20141014
LR  - 20140818
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 54
IP  - 8
DP  - 2014 Aug
TI  - Infusion technique of hematopoietic progenitor cells and related adverse events 
      (CME).
PG  - 1997-2003; quiz 1996
LID - 10.1111/trf.12572 [doi]
AB  - BACKGROUND: The use of hematopoietic progenitor cell (HPC) transplant has risen 
      over the past two decades. A variety of adverse events (AEs) of varying severity 
      have been noted during HPC infusions. These AEs have been associated with several 
      factors such as the amount of dimethyl sulfoxide and white blood cells in the HPC 
      product. We performed a single-institution retrospective analysis to determine 
      the effect of two different HPC infusion techniques, manual push with syringes 
      versus infusion from bags with the aid of gravity, on the occurrence of 
      infusion-related AEs. STUDY DESIGN AND METHODS: Infusions between December 2008 
      and November 2010 involving peripheral blood HPCs were reviewed. Pertinent 
      clinical and HPC product-related information was recorded. Data were analyzed to 
      determine the incidence of infusion-related AEs and its association with patient 
      and product-related variables. RESULTS: We found 461 AEs in 645 patients during 
      the study period. A total of 325 (50%) experienced at least one AE. Flushing was 
      the most common type of AE followed by nausea and hypertension. The use of 
      syringe infusion was more commonly associated with AEs (odds ratio, 1.82 [95% 
      confidence interval, 1.32-2.50]; p=0.002). Other independent risk factors were 
      cryopreserved products and the amount of polymorphonuclear leukocytes in the 
      product. CONCLUSION: To our knowledge, this is the first study examining the 
      effect of two different infusion techniques on infusion-related AEs. Our findings 
      suggest that the use of bags for infusion protected the patients from AEs.
CI  - (c) 2014 AABB.
FAU - Mulay, Sudhanshu B
AU  - Mulay SB
AD  - Division of Hematology/Oncology, University of Connecticut Health Center, 
      Farmington, Connecticut.
FAU - Greiner, Carl W
AU  - Greiner CW
FAU - Mohr, Amy
AU  - Mohr A
FAU - Bryant, Sandra C
AU  - Bryant SC
FAU - Lingineni, Ravi K
AU  - Lingineni RK
FAU - Padley, Doug
AU  - Padley D
FAU - Hogan, William J
AU  - Hogan WJ
FAU - Gastineau, Dennis A
AU  - Gastineau DA
FAU - Jacob, Eapen K
AU  - Jacob EK
LA  - eng
PT  - Journal Article
DEP - 20140217
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (Cryoprotective Agents)
RN  - 0 (Isotonic Solutions)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 68073-09-6 (normosol R)
RN  - 7LXU5N7ZO5 (Furosemide)
RN  - 8GTS82S83M (Diphenhydramine)
RN  - WI4X0X7BPJ (Hydrocortisone)
RN  - YOW8V9698H (Dimethyl Sulfoxide)
SB  - IM
MH  - Acetaminophen/therapeutic use
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Preservation/instrumentation/methods
MH  - Child
MH  - Child, Preschool
MH  - Cryopreservation
MH  - Cryoprotective Agents/adverse effects
MH  - Dimethyl Sulfoxide/adverse effects
MH  - Diphenhydramine/therapeutic use
MH  - Flushing/*etiology
MH  - Furosemide/therapeutic use
MH  - Hematologic Neoplasms/surgery
MH  - Humans
MH  - Hydrocortisone/therapeutic use
MH  - Hypertension/*etiology
MH  - Infant
MH  - Infant, Newborn
MH  - Infusions, Intravenous/*adverse effects/methods
MH  - Isotonic Solutions/adverse effects
MH  - Middle Aged
MH  - Nausea/*etiology
MH  - Neutrophils/immunology/transplantation
MH  - Peripheral Blood Stem Cell Transplantation/*adverse effects/methods
MH  - Premedication
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Syringes
MH  - Young Adult
EDAT- 2014/04/05 06:00
MHDA- 2014/10/15 06:00
CRDT- 2014/04/05 06:00
PHST- 2013/06/18 00:00 [received]
PHST- 2013/12/10 00:00 [revised]
PHST- 2013/12/12 00:00 [accepted]
PHST- 2014/04/05 06:00 [entrez]
PHST- 2014/04/05 06:00 [pubmed]
PHST- 2014/10/15 06:00 [medline]
AID - 10.1111/trf.12572 [doi]
PST - ppublish
SO  - Transfusion. 2014 Aug;54(8):1997-2003; quiz 1996. doi: 10.1111/trf.12572. Epub 
      2014 Feb 17.