PMID- 24698466
OWN - NLM
STAT- MEDLINE
DCOM- 20140617
LR  - 20140505
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 113
IP  - 10
DP  - 2014 May 15
TI  - Correlation between extent of myocardial fibrosis assessed by cardiac magnetic 
      resonance and cardiac troponin T release in patients with nonischemic heart 
      failure.
PG  - 1697-704
LID - S0002-9149(14)00721-8 [pii]
LID - 10.1016/j.amjcard.2014.02.029 [doi]
AB  - Persistently high cardiac troponin T (cTnT) levels reflect myocardial damage in 
      heart failure (HF). The presence and extent of myocardial fibrosis assessed by 
      cardiac magnetic resonance (CMR) and high levels of cTnT predict poor prognosis 
      in various cardiomyopathies. However, the association between myocardial fibrosis 
      and transcardiac cTnT release has not been evaluated. This study investigated the 
      correlation between myocardial fibrosis and transcardiac cTnT release from 
      nonischemic failing myocardium. Serum cTnT levels were measured in aortic root 
      (Ao) and coronary sinus (CS) using highly sensitive assay (detection limit >5 
      ng/L) in 74 nonischemic patients with HF who underwent CMR. Transcardiac cTnT 
      release (DeltacTnT [CS-Ao]) represented the difference between CS and Ao-cTnT levels. 
      Myocardial fibrosis was quantified by late gadolinium enhancement (LGE) volume 
      and %LGE on CMR. cTnT was detectable in 65 patients (88%), and DeltacTnT (CS-Ao) 
      levels were available (DeltacTnT [CS-Ao] >0 ng/L) in 60 patients (81%). LGE was 
      observed in 42 patients (57%), and DeltacTnT (CS-Ao) levels were available in 41 
      LGE-positive patients (98%). In patients with available cTnT release, DeltacTnT 
      (CS-Ao) levels were significantly higher in LGE-positive patients than those in 
      LGE-negative patients (4.3 [2.2-5.5] vs 1.5 [0.9-2.6] ng/L; p = 0.001). Log 
      (DeltacTnT [CS-Ao]) levels were correlated with LGE volume (r = 0.460, p = 0.003) and 
      %LGE (r = 0.356, p = 0.03). In conclusion, the amount of transcardiac cTnT 
      release was higher in LGE-positive patients than LGE-negative patients and 
      correlated with the extent of LGE in nonischemic patients with HF. These results 
      suggested that ongoing myocardial damage correlates with the presence and extent 
      of myocardial fibrosis.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Takashio, Seiji
AU  - Takashio S
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Yamamuro, Megumi
AU  - Yamamuro M
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan. Electronic address: 
      yamamuro@kumamoto-u.ac.jp.
FAU - Uemura, Tomoaki
AU  - Uemura T
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Utsunomiya, Daisuke
AU  - Utsunomiya D
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, Kumamoto, Japan.
FAU - Morita, Kosuke
AU  - Morita K
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, Kumamoto, Japan.
FAU - Izumiya, Yasuhiro
AU  - Izumiya Y
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Sugiyama, Seigo
AU  - Sugiyama S
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Kojima, Sunao
AU  - Kojima S
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Yamamoto, Eiichiro
AU  - Yamamoto E
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Tsujita, Kenichi
AU  - Tsujita K
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Tanaka, Tomoko
AU  - Tanaka T
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Tayama, Shinji
AU  - Tayama S
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Kaikita, Koichi
AU  - Kaikita K
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Hokimoto, Seiji
AU  - Hokimoto S
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Yasuda, Osamu
AU  - Yasuda O
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Yamashita, Yasuyuki
AU  - Yamashita Y
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, Kumamoto, Japan.
FAU - Ogawa, Hisao
AU  - Ogawa H
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140302
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Troponin T)
SB  - IM
MH  - Cardiac Catheterization
MH  - Cardiomyopathies/blood/*diagnosis
MH  - Female
MH  - Fibrosis/blood/diagnosis
MH  - Follow-Up Studies
MH  - Heart Failure/blood/*diagnosis
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/metabolism/*pathology
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Troponin T/*blood
EDAT- 2014/04/05 06:00
MHDA- 2014/06/18 06:00
CRDT- 2014/04/05 06:00
PHST- 2014/01/12 00:00 [received]
PHST- 2014/02/21 00:00 [revised]
PHST- 2014/02/21 00:00 [accepted]
PHST- 2014/04/05 06:00 [entrez]
PHST- 2014/04/05 06:00 [pubmed]
PHST- 2014/06/18 06:00 [medline]
AID - S0002-9149(14)00721-8 [pii]
AID - 10.1016/j.amjcard.2014.02.029 [doi]
PST - ppublish
SO  - Am J Cardiol. 2014 May 15;113(10):1697-704. doi: 10.1016/j.amjcard.2014.02.029. 
      Epub 2014 Mar 2.