PMID- 24699024
OWN - NLM
STAT- MEDLINE
DCOM- 20140521
LR  - 20140404
IS  - 1556-8539 (Print)
IS  - 1556-8539 (Linking)
VI  - 8
IP  - 3-4
DP  - 2013
TI  - Hematological malignancies: disease pathophysiology of leukemic stem cells.
PG  - 151-87
LID - jsc.2014.8.3/4.151 [pii]
AB  - Hematopoietic homeostasis is maintained throughout the lifetime of an individual 
      through self-renewal of hematopoietic stem cells. Defects in the self - renewal 
      and differentiation lead to hematopoietic insufficiency and development of 
      malignancies. Leukemic stem cells (LSCs), which are considered to originate from 
      hematopoietic stem or progenitor cells, not only adopt the regulatory machinery 
      operating in normal HSCs but establish their own mechanisms against apoptosis and 
      senescence. Hematopoietic malignancies are of Lymphoid origin with CLL and ALL 
      and myeloid malignancies with AML and CML and in addition there are disease of 
      the plasma multiple myelomas. One of the major therapeutic strategies for 
      hematological malignancies is hematopoietic stem cell transplantation along with 
      combination of chemotherapy. The review gives an insight of different 
      hematological malignancies, the mechanism and therapeutic strategies available at 
      present.
FAU - Ramdass, Bharathi
AU  - Ramdass B
FAU - Chowdhary, Abhay
AU  - Chowdhary A
FAU - Koka, Prasad S
AU  - Koka PS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Stem Cells
JT  - Journal of stem cells
JID - 101295936
SB  - IM
MH  - Animals
MH  - Hematologic Neoplasms/metabolism/*pathology/*physiopathology
MH  - Humans
MH  - Leukemia/metabolism/*pathology/*physiopathology
MH  - Neoplastic Stem Cells/metabolism/*pathology
MH  - Signal Transduction
EDAT- 2014/04/05 06:00
MHDA- 2014/05/23 06:00
CRDT- 2014/04/05 06:00
PHST- 2014/04/05 06:00 [entrez]
PHST- 2014/04/05 06:00 [pubmed]
PHST- 2014/05/23 06:00 [medline]
AID - jsc.2014.8.3/4.151 [pii]
PST - ppublish
SO  - J Stem Cells. 2013;8(3-4):151-87.