PMID- 24699361
OWN - NLM
STAT- MEDLINE
DCOM- 20150119
LR  - 20140418
IS  - 1878-3503 (Electronic)
IS  - 0035-9203 (Linking)
VI  - 108
IP  - 5
DP  - 2014 May
TI  - Association of human leukocyte antigen class II allele and haplotypes in 
      chikungunya viral infection in a western Indian population.
PG  - 277-82
LID - 10.1093/trstmh/tru030 [doi]
AB  - BACKGROUND: Genes coding for human leukocyte antigen (HLA) class II molecules are 
      polymorphic and have been shown to influence susceptibility to viral diseases. 
      METHODS: One hundred patients with acute chikungunya with and without viral load 
      and 250 chikungunya negative controls from western India were studied for the 
      distribution of HLA class II alleles by PCR with sequence-specific primer (SSP) 
      method. RESULTS: Frequency of DRB1*11 allele group (patients vs controls: 
      p=0.002, Pc=0.036, OR=0.21) and haplotype DRB1*11/DQB1*03 (patients vs controls: 
      p=0.007, OR=0.15) were significantly low, while haplotype DRB1*04/DQB1*03 
      (patients vs controls: p=0.042, OR=1.94) was significantly high in the patient 
      population. HLA DQB1*04 allele was found only in the patient group with viral 
      load (n=17), suggesting possible involvement of the same with chikungunya virus 
      (CHIKV) replication. CONCLUSIONS: Association of HLA-DRB1*11 and the emergence of 
      DRB1*11/DQB1*03 & DRB1*04/DQB1*03 as resistant and susceptible haplotypes towards 
      CHIKV infection is being reported for the first time. Our results suggest that 
      genetic susceptibility and/or resistance to chikungunya infection may be 
      modulated by HLA class II alleles.
FAU - Thanapati, Subrat
AU  - Thanapati S
AD  - Hepatitis Group, National Institute of Virology, Pune, 130/1, Sus Road, Pashan, 
      Pune, Maharashtra, India-411021.
FAU - Hande, Aparna
AU  - Hande A
FAU - Das, Rumki
AU  - Das R
FAU - Gurav, Yogesh
AU  - Gurav Y
FAU - Tripathy, Anuradha S
AU  - Tripathy AS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140402
PL  - England
TA  - Trans R Soc Trop Med Hyg
JT  - Transactions of the Royal Society of Tropical Medicine and Hygiene
JID - 7506129
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Animals
MH  - Chikungunya Fever/epidemiology/genetics/*immunology
MH  - Child
MH  - Disease Outbreaks
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens
MH  - HLA-DRB1 Chains/*immunology
MH  - Humans
MH  - *Immunity, Innate/genetics/immunology
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Chikungunya
OT  - HLA class II
OT  - Human leukocyte antigen
OT  - western Indian population
EDAT- 2014/04/05 06:00
MHDA- 2015/01/20 06:00
CRDT- 2014/04/05 06:00
PHST- 2014/04/05 06:00 [entrez]
PHST- 2014/04/05 06:00 [pubmed]
PHST- 2015/01/20 06:00 [medline]
AID - tru030 [pii]
AID - 10.1093/trstmh/tru030 [doi]
PST - ppublish
SO  - Trans R Soc Trop Med Hyg. 2014 May;108(5):277-82. doi: 10.1093/trstmh/tru030. 
      Epub 2014 Apr 2.