PMID- 24700661
OWN - NLM
STAT- MEDLINE
DCOM- 20150221
LR  - 20140616
IS  - 1097-4547 (Electronic)
IS  - 0360-4012 (Linking)
VI  - 92
IP  - 8
DP  - 2014 Aug
TI  - Brain-derived neurotrophic factor gene polymorphism predicts interindividual 
      variation in the sleep electroencephalogram.
PG  - 1018-23
LID - 10.1002/jnr.23380 [doi]
AB  - Previous studies have suggested that brain-derived neurotrophic factor (BDNF) 
      participates in the homeostatic regulation of sleep. The objective of this study 
      was to investigate the influence of the Val66Met functional polymorphism of the 
      BDNF gene on sleep and sleep EEG parameters in a large population-based sample. 
      In total 337 individuals participating in the Sao Paulo Epidemiologic Sleep Study 
      were selected for analysis. None of the participants had indications of a sleep 
      disorder, as measured by full-night polysomnography and questionnaire. Spectral 
      analysis of the EEG was carried out in all individuals using fast Fourier 
      transformation of the oscillatory signals for each EEG electrode. Sleep and sleep 
      EEG parameters in individuals with the Val/Val genotype were compared with those 
      in Met carriers (Val/Met and Met/Met genotypes). After correction for multiple 
      comparisons and for potential confounding factors, Met carriers showed decreased 
      spectral power in the alpha band in stage one and decreased theta power in stages 
      two and three of nonrapid-eye-movement sleep, at the central recording electrode. 
      No significant influence on sleep macrostructure was observed among the genotype 
      groups. Thus, the Val66Met polymorphism seems to modulate the electrical activity 
      of the brain, predicting interindividual variation of sleep EEG parameters. 
      Further studies of this and other polymorphic variants in potential candidate 
      genes will help the characterization of the molecular basis of sleep.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Guindalini, Camila
AU  - Guindalini C
AD  - Departamento de Psicobiologia, Universidade Federal de Sao Paulo (UNIFESP), Sao 
      Paulo, Brazil.
FAU - Mazzotti, Diego R
AU  - Mazzotti DR
FAU - Castro, Laura S
AU  - Castro LS
FAU - D'Aurea, Carolina V R
AU  - D'Aurea CV
FAU - Andersen, Monica L
AU  - Andersen ML
FAU - Poyares, Dalva
AU  - Poyares D
FAU - Bittencourt, Lia R A
AU  - Bittencourt LR
FAU - Tufik, Sergio
AU  - Tufik S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140403
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Electroencephalography
MH  - Female
MH  - Genetic Association Studies
MH  - Genotype
MH  - Humans
MH  - *Individuality
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Sleep/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - EEG
OT  - genetics
OT  - polymorphism
OT  - sleep
EDAT- 2014/04/05 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/04/05 06:00
PHST- 2013/10/23 00:00 [received]
PHST- 2014/01/29 00:00 [revised]
PHST- 2014/02/21 00:00 [accepted]
PHST- 2014/04/05 06:00 [entrez]
PHST- 2014/04/05 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - 10.1002/jnr.23380 [doi]
PST - ppublish
SO  - J Neurosci Res. 2014 Aug;92(8):1018-23. doi: 10.1002/jnr.23380. Epub 2014 Apr 3.