PMID- 24701345
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140404
LR  - 20211021
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2014
DP  - 2014
TI  - Microcystic changes in the retinal internal nuclear layer associated with optic 
      atrophy: a prospective study.
PG  - 395189
LID - 10.1155/2014/395189 [doi]
LID - 395189
AB  - Purpose. This study aimed at assessing the prevalence of pathologies presenting 
      retinal inner nuclear layer (RINL) microcystic perimacular changes associated 
      with optic nerve atrophy (OA). The charts of patients presenting a significant 
      defect of the Retinal Nerve Fiber Layer (RNFL) were included prospectively in 
      this study. Patients were classified according to the etiology of the RNFL 
      defect. Two hundred and one eyes of 138 patients were enrolled in this analysis. 
      Retinal images obtained showed the typical hyporeflective perifoveal 
      crescent-shaped lesion composed of small round hyporeflective microcysts confined 
      to the RINL in 35.3% of the eyes. Those findings were found in 75% of eyes 
      presenting hereditary OA, 50% of eyes presenting ischemic optic neuritis, 50% of 
      eyes with drusen of the optic nerve (ON), 44.4% of eyes presenting a compressive 
      OA, 32% of eyes presenting inflammatory optic neuropathy from multiple sclerosis, 
      18.5% of eyes presenting OA from undetermined origin, and 17.6% of eyes having 
      primary open-angle glaucoma. This study demonstrates that microcystic changes in 
      RINL are not specific to a disease but are found in OA of various etiologies. 
      Moreover, their incidence was found to be dependent upon the cause of OA, with 
      the highest incidence occurring in genetic OA.
FAU - Wolff, Benjamin
AU  - Wolff B
AD  - Rothschild Ophthalmologic Foundation, Professor Sahel Department, 25 rue Manin, 
      75019 Paris, France.
FAU - Azar, Georges
AU  - Azar G
AD  - Rothschild Ophthalmologic Foundation, Professor Sahel Department, 25 rue Manin, 
      75019 Paris, France.
FAU - Vasseur, Vivien
AU  - Vasseur V
AD  - Rothschild Ophthalmologic Foundation, Professor Sahel Department, 25 rue Manin, 
      75019 Paris, France.
FAU - Sahel, Jose-Alain
AU  - Sahel JA
AD  - Rothschild Ophthalmologic Foundation, Professor Sahel Department, 25 rue Manin, 
      75019 Paris, France.
FAU - Vignal, Catherine
AU  - Vignal C
AD  - Rothschild Ophthalmologic Foundation, Neuroophthalmology Department, 25 rue 
      Manin, 75019 Paris, France.
FAU - Mauget-Faysse, Martine
AU  - Mauget-Faysse M
AD  - Rothschild Ophthalmologic Foundation, Professor Sahel Department, 25 rue Manin, 
      75019 Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20140223
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC3950921
EDAT- 2014/04/05 06:00
MHDA- 2014/04/05 06:01
PMCR- 2014/02/23
CRDT- 2014/04/05 06:00
PHST- 2013/10/27 00:00 [received]
PHST- 2013/12/26 00:00 [revised]
PHST- 2014/01/16 00:00 [accepted]
PHST- 2014/04/05 06:00 [entrez]
PHST- 2014/04/05 06:00 [pubmed]
PHST- 2014/04/05 06:01 [medline]
PHST- 2014/02/23 00:00 [pmc-release]
AID - 10.1155/2014/395189 [doi]
PST - ppublish
SO  - J Ophthalmol. 2014;2014:395189. doi: 10.1155/2014/395189. Epub 2014 Feb 23.