PMID- 2470139
OWN - NLM
STAT- MEDLINE
DCOM- 19890619
LR  - 20190818
IS  - 0300-9475 (Print)
IS  - 0300-9475 (Linking)
VI  - 29
IP  - 4
DP  - 1989 Apr
TI  - Functional heterogeneity in allospecific cytotoxic T lymphocyte clones. III. 
      Direct correlation between development of syngeneic cytotoxicity and loss of veto 
      activity; implications for the mechanism of veto action.
PG  - 493-7
AB  - Two veto active allospecific cytotoxic T-cell clones (CTL), 4A2 and 4B3, were 
      studied for the development of autoreactivity. The 4A2 CTL became autoreactive 
      within 6 days when cultured without appropriate allospecific stimulator cells, 
      whereas the 4B3 CTL retained its alloreactivity without becoming autoreactive 
      when cultured under these conditions. Simultaneously with the development of 
      autoreactivity, the 4A2 CTL lost its veto activity. Limiting dilution cultures of 
      normal allospecific 4A2 CTL cells and autoreactive 4A2 CTL cells and mixtures of 
      both showed that the former CTL cells were capable of inhibiting clonal growth of 
      the autoreactive CTL cells in a dose-dependent manner. We suggest that this 
      growth inhibition reflects veto activity, i.e. cells capable of growing are 
      inhibited by autorecognition of veto active allospecific 4A2 CTL cells. Taken 
      together, the present results indicate that the existence of intraclonal 
      down-regulation of potentially autoreactive cells is a normal feature of 
      allospecific cytotoxic T-cell clones.
FAU - Claesson, M H
AU  - Claesson MH
AD  - Department of Medical Anatomy A, University of Copenhagen, Denmark.
FAU - Miller, R G
AU  - Miller RG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Epitopes)
RN  - 0 (Isoantigens)
SB  - IM
MH  - Animals
MH  - Cell Survival
MH  - Cells, Cultured
MH  - Clone Cells/classification/immunology
MH  - Cytotoxicity Tests, Immunologic
MH  - *Cytotoxicity, Immunologic
MH  - Epitopes/*immunology
MH  - Isoantigens/*immunology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - T-Lymphocytes, Cytotoxic/classification/*immunology
EDAT- 1989/04/01 00:00
MHDA- 1989/04/01 00:01
CRDT- 1989/04/01 00:00
PHST- 1989/04/01 00:00 [pubmed]
PHST- 1989/04/01 00:01 [medline]
PHST- 1989/04/01 00:00 [entrez]
AID - 10.1111/j.1365-3083.1989.tb01150.x [doi]
PST - ppublish
SO  - Scand J Immunol. 1989 Apr;29(4):493-7. doi: 10.1111/j.1365-3083.1989.tb01150.x.