PMID- 24702030
OWN - NLM
STAT- MEDLINE
DCOM- 20141001
LR  - 20140430
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 62
IP  - 17
DP  - 2014 Apr 30
TI  - Aceriphyllum rossii extract and its active compounds, quercetin and kaempferol 
      inhibit IgE-mediated mast cell activation and passive cutaneous anaphylaxis.
PG  - 3750-8
LID - 10.1021/jf405486c [doi]
AB  - Aceriphyllum rossii contains an abundant source of natural flavonoids with 
      potential antioxidant, anticancer and anti-inflammatory properties. However, the 
      effect of A. rossii extract (ARE) on immunoglobulin E(IgE)-mediated allergic 
      responses remains unknown. In the present study, the effects of ARE and its 
      active compounds, quercetin and kaempferol, on IgE-mediated rat basophilic 
      leukemia mast cell activation and passive cutaneous anaphylaxis (PCA) were 
      investigated. ARE, quercetin, and kaempferol inhibited secretion of 
      beta-hexosaminidase and histamine, and reduced the production and mRNA expression of 
      interleukin-4 and tumor necrosis factor-alpha. ARE also decreased the production of 
      prostaglandin E2 and leukotriene B4 and expression of cyclooxygenase 2 and 
      5-lipoxygenase. Furthermore, ARE, quercetin, and kaempferol inhibited 
      IgE-mediated phosphorylation of Syk, phospholipase Cgamma, protein kinase C (PKC)mu, 
      and the mitogen-activated protein kinases, extracellular signal-regulated kinase, 
      p38, and c-Jun N-terminal kinase. ARE, quercetin, and kaempferol markedly 
      suppressed mast cell-dependent PCA in IgE-sensitized mice. These results indicate 
      that ARE and its active constituents, quercetin and kaempferol, may be a useful 
      therapy for immediate-type hypersensitivity.
FAU - Kim, Myungsuk
AU  - Kim M
AD  - Functional Food Center, Korea Institute of Science and Technology (KIST), 
      Gangneung Institute , Gangwon Korea.
FAU - Lim, Sue Ji
AU  - Lim SJ
FAU - Kang, Suk Woo
AU  - Kang SW
FAU - Um, Byung-Hun
AU  - Um BH
FAU - Nho, Chu Won
AU  - Nho CW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140417
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Kaempferols)
RN  - 0 (Plant Extracts)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 731P2LE49E (kaempferol)
RN  - 820484N8I3 (Histamine)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
MH  - Anaphylaxis/*drug therapy/immunology
MH  - Animals
MH  - Anti-Allergic Agents/*administration & dosage
MH  - Histamine/immunology
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Interleukin-4/immunology
MH  - Kaempferols/*administration & dosage
MH  - Male
MH  - Mast Cells/drug effects/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plant Extracts/*administration & dosage
MH  - Quercetin/*administration & dosage
MH  - Rats
MH  - Saxifragaceae
MH  - Skin/drug effects/*immunology
EDAT- 2014/04/08 06:00
MHDA- 2014/10/02 06:00
CRDT- 2014/04/08 06:00
PHST- 2014/04/08 06:00 [entrez]
PHST- 2014/04/08 06:00 [pubmed]
PHST- 2014/10/02 06:00 [medline]
AID - 10.1021/jf405486c [doi]
PST - ppublish
SO  - J Agric Food Chem. 2014 Apr 30;62(17):3750-8. doi: 10.1021/jf405486c. Epub 2014 
      Apr 17.