PMID- 24702539
OWN - NLM
STAT- MEDLINE
DCOM- 20150107
LR  - 20211203
IS  - 1563-5260 (Electronic)
IS  - 0167-7063 (Print)
IS  - 0167-7063 (Linking)
VI  - 28
IP  - 1-2
DP  - 2014 Mar-Jun
TI  - Toward the identification of peripheral epigenetic biomarkers of schizophrenia.
PG  - 41-52
LID - 10.3109/01677063.2014.892485 [doi]
AB  - Schizophrenia (SZ) is a heritable, nonmendelian, neurodevelopmental disorder in 
      which epigenetic dysregulation of the brain genome plays a fundamental role in 
      mediating the clinical manifestations and course of the disease. The authors 
      recently reported that two enzymes that belong to the dynamic DNA 
      methylation/demethylation network-DNMT (DNA methyltransferase) and TET 
      (ten-eleven translocase; 5-hydroxycytosine translocator)-are abnormally increased 
      in corticolimbic structures of SZ postmortem brain, suggesting a causal 
      relationship between clinical manifestations of SZ and changes in DNA methylation 
      and in the expression of SZ candidate genes (e.g., brain-derived neurotrophic 
      factor [BDNF], glucocorticoid receptor [GCR], glutamic acid decarboxylase 67 
      [GAD67], reelin). Because the clinical manifestations of SZ typically begin with 
      a prodrome followed by a first episode in adolescence with subsequent 
      deterioration, it is obvious that the natural history of this disease cannot be 
      studied only in postmortem brain. Hence, the focus is currently shifting towards 
      the feasibility of studying epigenetic molecular signatures of SZ in blood cells. 
      Initial studies show a significant enrichment of epigenetic changes in 
      lymphocytes in gene networks directly relevant to psychiatric disorders. 
      Furthermore, the expression of DNA-methylating/demethylating enzymes and SZ 
      candidate genes such as BDNF and GCR are altered in the same direction in both 
      brain and blood lymphocytes. The coincidence of these changes in lymphocytes and 
      brain supports the hypothesis that common environmental or genetic risk factors 
      are operative in altering the epigenetic components involved in orchestrating 
      transcription of specific genes in brain and peripheral tissues. The 
      identification of DNA methylation signatures for SZ in peripheral blood cells of 
      subjects with genetic and clinical high risk would clearly have potential for the 
      diagnosis of SZ early in its course and would be invaluable for initiating early 
      intervention and individualized treatment plans.
FAU - Guidotti, A
AU  - Guidotti A
AD  - Psychiatric Institute, Department of Psychiatry, School of Medicine, University 
      of Illinois , Chicago, Chicago, Illinois , USA.
FAU - Auta, J
AU  - Auta J
FAU - Davis, J M
AU  - Davis JM
FAU - Dong, E
AU  - Dong E
FAU - Gavin, D P
AU  - Gavin DP
FAU - Grayson, D R
AU  - Grayson DR
FAU - Sharma, R P
AU  - Sharma RP
FAU - Smith, R C
AU  - Smith RC
FAU - Tueting, P
AU  - Tueting P
FAU - Zhubi, A
AU  - Zhubi A
LA  - eng
GR  - R01-MH093341/MH/NIMH NIH HHS/United States
GR  - R01-MH094358/MH/NIMH NIH HHS/United States
GR  - R01 MH094358/MH/NIMH NIH HHS/United States
GR  - R01 MH101043/MH/NIMH NIH HHS/United States
GR  - R01-MH101043/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20140422
PL  - England
TA  - J Neurogenet
JT  - Journal of neurogenetics
JID - 8406473
RN  - 0 (Biomarkers)
RN  - 0 (Reelin Protein)
RN  - EC 3.4.21.- (RELN protein, human)
SB  - IM
MH  - Biomarkers/*blood
MH  - DNA Methylation
MH  - Epigenesis, Genetic/*genetics
MH  - Gene Regulatory Networks
MH  - Humans
MH  - Lymphocytes/*metabolism
MH  - Reelin Protein
MH  - *Schizophrenia/blood/genetics/metabolism
PMC - PMC4112595
MID - NIHMS602725
OTO - NOTNLM
OT  - DNA methylation
OT  - brain-derived nerve growth factor
OT  - glucocorticoid receptor
OT  - lymphocytes
EDAT- 2014/04/08 06:00
MHDA- 2015/01/08 06:00
PMCR- 2014/07/28
CRDT- 2014/04/08 06:00
PHST- 2014/04/08 06:00 [entrez]
PHST- 2014/04/08 06:00 [pubmed]
PHST- 2015/01/08 06:00 [medline]
PHST- 2014/07/28 00:00 [pmc-release]
AID - 10.3109/01677063.2014.892485 [doi]
PST - ppublish
SO  - J Neurogenet. 2014 Mar-Jun;28(1-2):41-52. doi: 10.3109/01677063.2014.892485. Epub 
      2014 Apr 22.