PMID- 24702900
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20140509
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 96
IP  - 3
DP  - 2014 Jun
TI  - Interaction between single-dose Mycoplasma hyopneumoniae and porcine reproductive 
      and respiratory syndrome virus vaccines on dually infected pigs.
PG  - 516-22
LID - S0034-5288(14)00057-5 [pii]
LID - 10.1016/j.rvsc.2014.03.009 [doi]
AB  - The objective of this study was to determine the effects of Mycoplasma 
      hyopneumoniae and/or porcine reproductive and respiratory syndrome virus (PRRSV) 
      vaccination on dually infected pigs. In total, 72 pigs were randomly divided into 
      nine groups (eight pigs per group), as follows: five vaccinated and challenged 
      groups, three non-vaccinated and challenged groups, and a negative control group. 
      Single-dose vaccination against M. hyopneumoniae alone decreased the levels of 
      PRRSV viremia and PRRSV-induced pulmonary lesions, whereas single-dose 
      vaccination against PRRSV alone did not decrease nasal shedding of M. 
      hyopneumoniae and mycoplasma-induced pulmonary lesions in the dually infected 
      pigs. The M. hyopneumoniae challenge impaired the protective cell-mediated 
      immunity induced by the PRRSV vaccine, whereas the PRRSV challenge did not impair 
      the protective cell-mediated immunity induced by the M. hyopneumoniae vaccine. 
      The present study provides swine practitioners and producers with efficient 
      vaccination regimes; vaccination against M. hyopneumoniae is the first step in 
      protecting pigs against co-infection with M. hyopneumoniae and PRRSV.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Park, Su-Jin
AU  - Park SJ
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Seo, Hwi Won
AU  - Seo HW
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Park, Changhoon
AU  - Park C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea. 
      Electronic address: swine@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140402
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Bacterial Vaccines)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Bacterial/blood
MH  - Antibodies, Viral/blood
MH  - Bacterial Vaccines/administration & dosage/*immunology/standards
MH  - Coinfection/immunology/microbiology/*veterinary/virology
MH  - Enzyme-Linked Immunosorbent Assay/veterinary
MH  - Immunohistochemistry/veterinary
MH  - Lung/microbiology/pathology/virology
MH  - Mycoplasma hyopneumoniae/*immunology
MH  - Pneumonia of Swine, Mycoplasmal/*immunology/microbiology/prevention & control
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology/prevention & 
      control/virology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Random Allocation
MH  - Swine
MH  - Viral Vaccines/administration & dosage/*immunology/standards
OTO - NOTNLM
OT  - Mycoplasma hyopneumoniae
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Porcine respiratory disease complex
OT  - Vaccine
EDAT- 2014/04/08 06:00
MHDA- 2015/01/06 06:00
CRDT- 2014/04/08 06:00
PHST- 2013/12/19 00:00 [received]
PHST- 2014/02/20 00:00 [revised]
PHST- 2014/03/10 00:00 [accepted]
PHST- 2014/04/08 06:00 [entrez]
PHST- 2014/04/08 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
AID - S0034-5288(14)00057-5 [pii]
AID - 10.1016/j.rvsc.2014.03.009 [doi]
PST - ppublish
SO  - Res Vet Sci. 2014 Jun;96(3):516-22. doi: 10.1016/j.rvsc.2014.03.009. Epub 2014 
      Apr 2.