PMID- 24703173
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20221207
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 43
DP  - 2014 May
TI  - BDNF in late-life depression: effect of SSRI usage and interaction with childhood 
      abuse.
PG  - 81-9
LID - S0306-4530(14)00052-3 [pii]
LID - 10.1016/j.psyneuen.2014.02.001 [doi]
AB  - Brain-Derived Neurotrophic Factor (BDNF) serum levels are abnormally low in 
      depressed patients as compared to healthy controls and normalize with SSRI 
      treatment. The aim of this study is to examine serum BDNF levels in late-life 
      depression, stratified for SSRI usage, and to explore the relation between BDNF 
      levels and specific depression characteristics as well as between BDNF levels and 
      early and recent life stressors in late-life depression. We assessed serum BDNF 
      levels in 259 depressed patients not using an SSRI, 99 depressed patients using 
      an SSRI and 119 non-depressed controls (age range 60-93 years). Depressive 
      disorders were diagnosed with the Composite International Diagnostic Interview 
      (CIDI, version 2.1). Serum BDNF levels were significantly higher in depressed 
      patients who used an SSRI compared to depressed patients not using SSRIs and 
      compared to non-depressed controls, when adjusted for age, sex, life style 
      characteristics, cognitive functioning and somatic comorbidity. Recent 
      life-events, assessed with the List of Threatening Events-Questionnaire, were 
      significantly associated with lower BDNF levels in non-depressed subjects only. 
      Although a summary score of early traumatization (before the age of 16 years) was 
      not associated with serum BDNF levels in any of the three groups, we found an 
      interaction between a history of severe physical abuse and SSRI usage in the 
      depressed group. Interestingly, higher serum levels of BDNF in depressed patients 
      using SSRIs were only found in those patients without a history of severe 
      childhood abuse and not in those with a history of severe childhood abuse.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - van der Meij, Annemarie
AU  - van der Meij A
AD  - Pro Persona, Department of Psychiatry, Nijmegen, The Netherlands; Department of 
      Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The 
      Netherlands.
FAU - Comijs, Hannie C
AU  - Comijs HC
AD  - GGZ Ingeest, Department of Psychiatry & EMGO Institute of Health and Care 
      Research, VU Medical Centre, Amsterdam, The Netherlands.
FAU - Dols, Annemieke
AU  - Dols A
AD  - GGZ Ingeest, Department of Psychiatry & EMGO Institute of Health and Care 
      Research, VU Medical Centre, Amsterdam, The Netherlands.
FAU - Janzing, Joost G E
AU  - Janzing JG
AD  - Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, 
      The Netherlands.
FAU - Oude Voshaar, Richard C
AU  - Oude Voshaar RC
AD  - Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, 
      The Netherlands; University Centre of Psychiatry, University Medical Centre 
      Groningen, University of Groningen, Groningen, The Netherlands. Electronic 
      address: r.c.oude.voshaar@umcg.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140211
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Uptake Inhibitors)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Child Abuse/*psychology
MH  - Depressive Disorder/*drug therapy/*metabolism
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Selective Serotonin Reuptake Inhibitors/*therapeutic use
MH  - Socioeconomic Factors
MH  - Stress, Psychological/blood/psychology
OTO - NOTNLM
OT  - Aged
OT  - Aged, 80 years and over
OT  - Brain-Derived Neurotrophic Factor
OT  - Child abuse
OT  - Depression, major depressive disorder
OT  - Serotonin uptake inhibitors
EDAT- 2014/04/08 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/04/08 06:00
PHST- 2013/10/16 00:00 [received]
PHST- 2014/01/11 00:00 [revised]
PHST- 2014/02/03 00:00 [accepted]
PHST- 2014/04/08 06:00 [entrez]
PHST- 2014/04/08 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0306-4530(14)00052-3 [pii]
AID - 10.1016/j.psyneuen.2014.02.001 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2014 May;43:81-9. doi: 10.1016/j.psyneuen.2014.02.001. 
      Epub 2014 Feb 11.