PMID- 24703465
OWN - NLM
STAT- MEDLINE
DCOM- 20140730
LR  - 20211021
IS  - 1349-7006 (Electronic)
IS  - 1347-9032 (Print)
IS  - 1347-9032 (Linking)
VI  - 105
IP  - 6
DP  - 2014 Jun
TI  - MGr1-Ag/37LRP induces cell adhesion-mediated drug resistance through FAK/PI3K and 
      MAPK pathway in gastric cancer.
PG  - 651-9
LID - 10.1111/cas.12414 [doi]
AB  - It is well known that tumor microenvironment plays a vital role in drug 
      resistance and cell adhesion-mediated drug resistance (CAM-DR), a form of de novo 
      drug resistance. In our previous study, we reported that MGr1-Ag/37LRP 
      ligation-induced adhesion participated in protecting gastric cancer cells from a 
      number of apoptotic stimuli caused by chemotherapeutic drugs. Further study 
      suggested that MGr1-Ag could prompt CAM-DR through interaction with laminin. 
      However, the MGr1-Ag-initiated intracellular signal transduction pathway is still 
      unknown. In this study, our experimental results showed that gastric cancer MDR 
      cell lines mediated CAM-DR through upregulation of Bcl-2 by MGr1-Ag interaction 
      with laminin. Further study found that, as a receptor of ECM components, 
      MGr1-Ag/37LRP may activate the downstream signal pathway PI3K/AKT and MAPK/ERK 
      through interaction with phosphorylated FAK. Moreover, the sensitivity to 
      chemotherapeutic drugs could be significantly enhanced by inhibiting 
      MGr1-Ag/37LRP expression through mAbs, siRNA, and antisense oligonucleotide. 
      According to these results, we concluded that the FAK/PI3K and MAPK signal 
      pathway plays an important role in MGr1-Ag-mediated CAM-DR in gastric cancer. 
      MGr1-Ag/37LRP might be a potential effective reversal target to MDR in gastric 
      cancer.
CI  - (c) 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on 
      behalf of Japanese Cancer Association.
FAU - Sun, Li
AU  - Sun L
AD  - State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, 
      Fourth Military Medical University, Xi'an, China.
FAU - Liu, Lili
AU  - Liu L
FAU - Liu, Xiangqiang
AU  - Liu X
FAU - Wang, Yafang
AU  - Wang Y
FAU - Li, Mengbin
AU  - Li M
FAU - Yao, Liping
AU  - Yao L
FAU - Yang, Jianjun
AU  - Yang J
FAU - Ji, Genlin
AU  - Ji G
FAU - Guo, Changcun
AU  - Guo C
FAU - Pan, Yanglin
AU  - Pan Y
FAU - Liang, Shuhui
AU  - Liang S
FAU - Wang, Biaoluo
AU  - Wang B
FAU - Ding, Jie
AU  - Ding J
FAU - Zhang, Hongwei
AU  - Zhang H
FAU - Shi, Yongquan
AU  - Shi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140512
PL  - England
TA  - Cancer Sci
JT  - Cancer science
JID - 101168776
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Laminin)
RN  - 0 (MGr1-antigen, human)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (RPSA protein, human)
RN  - 0 (Receptors, Laminin)
RN  - 0 (Ribosomal Proteins)
RN  - 5J49Q6B70F (Vincristine)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.10.2 (Focal Adhesion Kinase 1)
RN  - EC 2.7.10.2 (PTK2 protein, human)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/immunology
MH  - Antigens, Neoplasm/genetics/*metabolism
MH  - Cell Adhesion
MH  - *Drug Resistance, Neoplasm
MH  - Focal Adhesion Kinase 1/metabolism
MH  - Humans
MH  - Laminin/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Nude
MH  - Mitogen-Activated Protein Kinases/*metabolism
MH  - Phosphatidylinositol 3-Kinases/*metabolism
MH  - Proto-Oncogene Proteins c-bcl-2/biosynthesis
MH  - RNA Interference
MH  - RNA, Small Interfering
MH  - Receptors, Laminin/genetics/*metabolism
MH  - Ribosomal Proteins/genetics/*metabolism
MH  - Signal Transduction
MH  - Stomach Neoplasms/*drug therapy/pathology
MH  - Tumor Cells, Cultured
MH  - Tumor Microenvironment
MH  - Up-Regulation
MH  - Vincristine/pharmacology
PMC - PMC4317895
OTO - NOTNLM
OT  - CAM-DR
OT  - FAK/PI3K
OT  - MAPK
OT  - MGr1-Ag/37LRP
OT  - gastric cancer
EDAT- 2014/04/08 06:00
MHDA- 2014/07/31 06:00
PMCR- 2014/06/01
CRDT- 2014/04/08 06:00
PHST- 2014/02/11 00:00 [received]
PHST- 2014/03/25 00:00 [revised]
PHST- 2014/04/03 00:00 [accepted]
PHST- 2014/04/08 06:00 [entrez]
PHST- 2014/04/08 06:00 [pubmed]
PHST- 2014/07/31 06:00 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - 10.1111/cas.12414 [doi]
PST - ppublish
SO  - Cancer Sci. 2014 Jun;105(6):651-9. doi: 10.1111/cas.12414. Epub 2014 May 12.