PMID- 24704380
OWN - NLM
STAT- MEDLINE
DCOM- 20141201
LR  - 20191210
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 570
DP  - 2014 Jun 6
TI  - Long-interval facilitation and inhibition are differentially affected by 
      conditioning stimulus intensity over different time courses.
PG  - 114-8
LID - S0304-3940(14)00259-6 [pii]
LID - 10.1016/j.neulet.2014.03.060 [doi]
AB  - Intracortical facilitatory and inhibitory processes in the primary motor cortex 
      (M1) play an important role in both the preparation and execution of motor tasks. 
      Here we aimed to (1) confirm the existence of, and further characterise, 
      intracortical facilitation at long conditioning-test stimulus intervals at 
      subthreshold conditioning stimulus (CS) intensities and (2) identify the 
      threshold for long-interval intracortical inhibition (LICI) at different 
      inter-stimulus intervals (ISIs). To examine facilitation, stimulus-response 
      curves at ISIs of 100 and 150 ms were obtained using a range of subthreshold CS 
      intensities. LICI stimulus-response curves were also obtained using varying CS 
      intensities at ISIs of 100 (LICI100) and 150 ms (LICI150). Facilitation of the 
      conditioned MEP was observed at subthreshold CS intensities at an ISI of 100 ms. 
      LICI100 was observed at a lower CS intensity than LICI150. First, we provide 
      evidence of a long-interval facilitation and provide some evidence consistent 
      with a cortical origin of this facilitation. Second, the lower threshold for 
      evoking LICI100 than LICI150 suggests an intensity-duration effect whereby a more 
      intense CS results in longer duration LICI. Investigation of the interaction 
      between LICI and long-interval facilitation might help to elucidate the 
      functional importance of these processes.
CI  - Copyright (c) 2014. Published by Elsevier Ireland Ltd.
FAU - Vallence, Ann-Maree
AU  - Vallence AM
AD  - The Robinson Institute, School of Paediatrics and Reproductive Health, University 
      of Adelaide, Adelaide, Australia. Electronic address: 
      ann-maree.vallence@adelaide.edu.au.
FAU - Schneider, Luke A
AU  - Schneider LA
AD  - The Robinson Institute, School of Paediatrics and Reproductive Health, University 
      of Adelaide, Adelaide, Australia.
FAU - Pitcher, Julia B
AU  - Pitcher JB
AD  - The Robinson Institute, School of Paediatrics and Reproductive Health, University 
      of Adelaide, Adelaide, Australia.
FAU - Ridding, Michael C
AU  - Ridding MC
AD  - The Robinson Institute, School of Paediatrics and Reproductive Health, University 
      of Adelaide, Adelaide, Australia.
LA  - eng
PT  - Journal Article
DEP - 20140403
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
SB  - IM
MH  - Adult
MH  - *Conditioning, Psychological
MH  - Evoked Potentials, Motor
MH  - Female
MH  - Humans
MH  - Male
MH  - *Neural Inhibition
MH  - Sensory Thresholds
MH  - Time Factors
MH  - Transcranial Direct Current Stimulation
MH  - Young Adult
OTO - NOTNLM
OT  - GABAergic inhibition
OT  - Long-interval facilitation
OT  - Long-interval intracortical inhibition
OT  - Primary motor cortex
OT  - Transcranial magnetic stimulation
EDAT- 2014/04/08 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/04/08 06:00
PHST- 2014/01/10 00:00 [received]
PHST- 2014/02/20 00:00 [revised]
PHST- 2014/03/25 00:00 [accepted]
PHST- 2014/04/08 06:00 [entrez]
PHST- 2014/04/08 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0304-3940(14)00259-6 [pii]
AID - 10.1016/j.neulet.2014.03.060 [doi]
PST - ppublish
SO  - Neurosci Lett. 2014 Jun 6;570:114-8. doi: 10.1016/j.neulet.2014.03.060. Epub 2014 
      Apr 3.