PMID- 24704638
OWN - NLM
STAT- MEDLINE
DCOM- 20140922
LR  - 20181202
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 68
DP  - 2014 Jul
TI  - Persistent organic pollutants measured in maternal serum and offspring 
      neurodevelopmental outcomes--a prospective study with long-term follow-up.
PG  - 41-8
LID - S0160-4120(14)00072-5 [pii]
LID - 10.1016/j.envint.2014.03.002 [doi]
AB  - Fetal exposure to persistent organic pollutants (POPs) has been linked to adverse 
      neurodevelopment, but few studies have had follow-up beyond childhood. The 
      purpose of this study was to examine the association of maternal serum 
      concentrations of two perfluoroalkyl acids (perfluorooctanoic acid (PFOA) and 
      perfluorooctane sulfonate (PFOS)), polychlorinated biphenyls (PCBs), 
      dichlorodiphenyldichloroethylene (p,p'-DDE) and hexachlorobenzene (HCB) with 
      offspring behavioural and affective disorders and scholastic achievement in a 
      prebirth cohort study with 20 years of follow up. Between 1988 and 1989 pregnant 
      women (n=965) were recruited for the prebirth Danish Fetal Origins 1988 (DaFO88) 
      Cohort in Aarhus, Denmark. Perfluoroalkyl acids, PCBs, p,p'-DDE, and HCB were 
      quantified in serum from week 30 of gestation (n=876 for perfluoroalkyl acids/872 
      for PCBs, p,p'-DDE, HCB). Offspring were followed up through national registries 
      until 2011. We evaluated associations between maternal serum concentrations of 
      these POPs and offspring neurodevelopmental outcomes, defined as: first admission 
      diagnosis or prescription of medication until age >20 for (1) ADHD; (2) 
      depression; and (3) scholastic achievement defined as mean grade on a 
      standardized written examination given in the 9th grade (final exams of 
      compulsory school in Denmark). Maternal concentrations of organochlorine 
      substances and perfluoroalkyl acids were higher than present day levels. During 
      the follow-up period there were 27 (3.1%) cases of ADHD and 104 (11.9%) cases of 
      depression; the mean scholastic achievement was 6.7 (SD 2.3). Overall we found no 
      association for maternal levels of any of the measured pollutants with offspring 
      behavioural and affective disorders or with scholastic achievement. Our analyses 
      based on biomarkers from a cohort of over 800 pregnant women with long-term close 
      to complete follow-up through national registries showed little evidence of a 
      programming effect of PFOA, PFOS, PCBs, p,p'-DDE, and HCB in relation to 
      clinically and functionally relevant offspring neurodevelopmental outcomes.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Strom, Marin
AU  - Strom M
AD  - Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum 
      Institut, DK-2300 Copenhagen S, Denmark. Electronic address: mrm@ssi.dk.
FAU - Hansen, Susanne
AU  - Hansen S
AD  - Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum 
      Institut, DK-2300 Copenhagen S, Denmark. Electronic address: suu@ssi.dk.
FAU - Olsen, Sjurethur Froethi
AU  - Olsen SF
AD  - Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum 
      Institut, DK-2300 Copenhagen S, Denmark; Department of Nutrition, Harvard School 
      of Public Health, Boston, MA 02115, USA. Electronic address: sfo@ssi.dk.
FAU - Haug, Line Smastuen
AU  - Haug LS
AD  - Department of Exposure and Risk Assessment, Norwegian Institute of Public Health, 
      NO-0406 Oslo, Norway. Electronic address: Line.Smastuen.Haug@fhi.no.
FAU - Rantakokko, Panu
AU  - Rantakokko P
AD  - Department of Environmental Health, National Institute for Health and Welfare, 
      FI-70701 Kuopio, Finland. Electronic address: panu.rantakokko@thl.fi.
FAU - Kiviranta, Hannu
AU  - Kiviranta H
AD  - Department of Environmental Health, National Institute for Health and Welfare, 
      FI-70701 Kuopio, Finland. Electronic address: hannu.kiviranta@thl.fi.
FAU - Halldorsson, Thorhallur Ingi
AU  - Halldorsson TI
AD  - Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum 
      Institut, DK-2300 Copenhagen S, Denmark; Faculty of Food Science and Nutrition, 
      University of Iceland, IS-101 Reykjavik, Iceland; Unit for Nutrition Research, 
      Landspitali University Hospital, IS-101 Reykjavik, Iceland. Electronic address: 
      lur@ssi.dk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140402
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Halogenated)
SB  - IM
MH  - Adult
MH  - Attention Deficit Disorder with Hyperactivity/etiology
MH  - Cohort Studies
MH  - Denmark
MH  - Depression/*etiology
MH  - Environmental Pollutants/blood/toxicity
MH  - Female
MH  - Follow-Up Studies
MH  - Gestational Age
MH  - Humans
MH  - *Hydrocarbons, Halogenated/blood/toxicity
MH  - Male
MH  - *Maternal Exposure
MH  - Nervous System/*drug effects/growth & development
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Proportional Hazards Models
MH  - Prospective Studies
OTO - NOTNLM
OT  - Attention deficit/hyperactivity disorder
OT  - Depression
OT  - Long-time follow-up
OT  - Neurodevelopmental outcomes
OT  - Persistent organic pollutants
OT  - Scholastic achievement
EDAT- 2014/04/08 06:00
MHDA- 2014/09/23 06:00
CRDT- 2014/04/08 06:00
PHST- 2013/12/20 00:00 [received]
PHST- 2014/02/28 00:00 [revised]
PHST- 2014/03/04 00:00 [accepted]
PHST- 2014/04/08 06:00 [entrez]
PHST- 2014/04/08 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
AID - S0160-4120(14)00072-5 [pii]
AID - 10.1016/j.envint.2014.03.002 [doi]
PST - ppublish
SO  - Environ Int. 2014 Jul;68:41-8. doi: 10.1016/j.envint.2014.03.002. Epub 2014 Apr 
      2.