PMID- 24704672
OWN - NLM
STAT- MEDLINE
DCOM- 20150226
LR  - 20140705
IS  - 1872-7492 (Electronic)
IS  - 0168-1702 (Linking)
VI  - 188
DP  - 2014 Aug 8
TI  - Preliminary exploration of HLA-A 1101-restricted human cytomegalovirus 
      glycoprotein B-specific CD8(+) T cells in allogeneic stem-cell transplant 
      recipients.
PG  - 38-44
LID - S0168-1702(14)00147-6 [pii]
LID - 10.1016/j.virusres.2014.03.027 [doi]
AB  - T-cell responses directed against human cytomegalovirus (HCMV) glycoprotein B 
      (gB) contribute to protective immunity against HCMV infection in both animal 
      models and humans. However, the gB-specific human CD8(+) T cell responses remain 
      poorly understood. gB antigen-specific CD8(+) T cells were stained with seven 
      major histocompatibility complex (MHC)-peptide pentamers in 16 human leukocyte 
      antigen (HLA)-A 1101-positive, HCMV-seropositive patients following hematopoietic 
      stem cell transplantation (HSCT). Of these seven pentamers, the most frequent 
      CD8(+) T-cell responses were directed against the gB332-340 peptide. These 
      gB332-340-specific CD8(+) T cells were strongly associated with the presence of 
      plasma HCMV immunoglobulin M in all HSCT recipients and exhibited a probable 
      causal relationship with the level of pp65 antigenemia. Together, these data 
      suggest a role for gB332-340-specific CD8(+) T cells in HCMV reactivation after 
      HSCT. Furthermore, the pentamer assay may be valuable in detecting 
      antigen-specific CD8(+) T cells.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Liu, Anbing
AU  - Liu A
AD  - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The 
      First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun 
      Road, Hangzhou 310003, China.
FAU - Hu, Jianhua
AU  - Hu J
AD  - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The 
      First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun 
      Road, Hangzhou 310003, China.
FAU - Wu, Wei
AU  - Wu W
AD  - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The 
      First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun 
      Road, Hangzhou 310003, China.
FAU - Huang, Yaping
AU  - Huang Y
AD  - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The 
      First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun 
      Road, Hangzhou 310003, China.
FAU - Liang, Hanying
AU  - Liang H
AD  - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The 
      First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun 
      Road, Hangzhou 310003, China.
FAU - Wang, Huiqi
AU  - Wang H
AD  - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The 
      First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun 
      Road, Hangzhou 310003, China.
FAU - Yang, Rong
AU  - Yang R
AD  - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The 
      First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun 
      Road, Hangzhou 310003, China.
FAU - Fan, Jun
AU  - Fan J
AD  - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The 
      First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun 
      Road, Hangzhou 310003, China. Electronic address: fanjunyz@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140401
PL  - Netherlands
TA  - Virus Res
JT  - Virus research
JID - 8410979
RN  - 0 (Antibodies, Viral)
RN  - 0 (HLA-A11 Antigen)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (glycoprotein B, Simplexvirus)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Viral/blood
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Cytomegalovirus/immunology/physiology
MH  - Female
MH  - HLA-A11 Antigen/*immunology
MH  - Humans
MH  - Immunoglobulin M/blood
MH  - Male
MH  - Middle Aged
MH  - Staining and Labeling
MH  - *Stem Cell Transplantation
MH  - T-Lymphocyte Subsets/immunology
MH  - *Transplant Recipients
MH  - *Transplantation, Homologous
MH  - Viral Envelope Proteins/*immunology
MH  - Virus Activation
MH  - Young Adult
OTO - NOTNLM
OT  - Allogeneic hematopoietic stem cell transplantation
OT  - CD8(+) T cell
OT  - Glycoprotein B
OT  - HLA-A*1101
OT  - Human cytomegalovirus
OT  - Pentamer
EDAT- 2014/04/08 06:00
MHDA- 2015/02/27 06:00
CRDT- 2014/04/08 06:00
PHST- 2013/11/22 00:00 [received]
PHST- 2014/03/16 00:00 [revised]
PHST- 2014/03/24 00:00 [accepted]
PHST- 2014/04/08 06:00 [entrez]
PHST- 2014/04/08 06:00 [pubmed]
PHST- 2015/02/27 06:00 [medline]
AID - S0168-1702(14)00147-6 [pii]
AID - 10.1016/j.virusres.2014.03.027 [doi]
PST - ppublish
SO  - Virus Res. 2014 Aug 8;188:38-44. doi: 10.1016/j.virusres.2014.03.027. Epub 2014 
      Apr 1.