PMID- 24705214
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140407
LR  - 20211021
IS  - 2073-4425 (Print)
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 4
IP  - 3
DP  - 2013 Sep 10
TI  - Polymorphisms in Fatty Acid Desaturase (FADS) Gene Cluster: Effects on Glycemic 
      Controls Following an Omega-3 Polyunsaturated Fatty Acids (PUFA) Supplementation.
PG  - 485-98
LID - 10.3390/genes4030485 [doi]
AB  - Changes in desaturase activity are associated with insulin sensitivity and may be 
      associated with type 2 diabetes mellitus (T2DM). Polymorphisms (SNPs) in the 
      fatty acid desaturase (FADS) gene cluster have been associated with the 
      homeostasis model assessment of insulin sensitivity (HOMA-IS) and serum fatty 
      acid composition. OBJECTIVE: To investigate whether common genetic variations in 
      the FADS gene cluster influence fasting glucose (FG) and fasting insulin (FI) 
      responses following a 6-week n-3 polyunsaturated fatty acids (PUFA) 
      supplementation. METHODS: 210 subjects completed a 2-week run-in period followed 
      by a 6-week supplementation with 5 g/d of fish oil (providing 1.9 g-2.2 g of EPA 
      + 1.1 g of DHA). Genotyping of 18 SNPs of the FADS gene cluster covering 90% of 
      all common genetic variations (minor allele frequency >/= 0.03) was performed. 
      RESULTS: Carriers of the minor allele for rs482548 (FADS2) had increased plasma 
      FG levels after the n-3 PUFA supplementation in a model adjusted for FG levels at 
      baseline, age, sex, and BMI. A significant genotype*supplementation interaction 
      effect on FG levels was observed for rs482548 (p = 0.008). For FI levels, a 
      genotype effect was observed with one SNP (rs174456). For HOMA-IS, several 
      genotype*supplementation interaction effects were observed for rs7394871, 
      rs174602, rs174570, rs7482316 and rs482548 (p = 0.03, p = 0.01, p = 0.03, p = 
      0.05 and p = 0.07; respectively). CONCLUSION: RESULTS suggest that SNPs in the 
      FADS gene cluster may modulate plasma FG, FI and HOMA-IS levels in response to 
      n-3 PUFA supplementation.
FAU - Cormier, Hubert
AU  - Cormier H
AD  - Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec 
      City, QC, G1V 0A6, Canada. hubert.cormier.1@ulaval.ca.
FAU - Rudkowska, Iwona
AU  - Rudkowska I
AD  - Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec 
      City, QC, G1V 0A6, Canada. iwona.rudkowska@fsaa.ulaval.ca.
FAU - Thifault, Elisabeth
AU  - Thifault E
AD  - Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec 
      City, QC, G1V 0A6, Canada. elisabeth.thifault@fsaa.ulaval.ca.
FAU - Lemieux, Simone
AU  - Lemieux S
AD  - Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec 
      City, QC, G1V 0A6, Canada. simone.lemieux@fsaa.ulaval.ca.
FAU - Couture, Patrick
AU  - Couture P
AD  - Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec 
      City, QC, G1V 0A6, Canada. patrick.couture@crchul.ulaval.ca.
FAU - Vohl, Marie-Claude
AU  - Vohl MC
AD  - Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec 
      City, QC, G1V 0A6, Canada. marie-claude.vohl@fsaa.ulaval.ca.
LA  - eng
PT  - Journal Article
DEP - 20130910
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
PMC - PMC3924828
EDAT- 2013/01/01 00:00
MHDA- 2013/01/01 00:01
PMCR- 2013/09/01
CRDT- 2014/04/08 06:00
PHST- 2013/06/08 00:00 [received]
PHST- 2013/08/22 00:00 [revised]
PHST- 2013/09/02 00:00 [accepted]
PHST- 2014/04/08 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2013/01/01 00:01 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - genes4030485 [pii]
AID - genes-04-00485 [pii]
AID - 10.3390/genes4030485 [doi]
PST - epublish
SO  - Genes (Basel). 2013 Sep 10;4(3):485-98. doi: 10.3390/genes4030485.