PMID- 2470597
OWN - NLM
STAT- MEDLINE
DCOM- 19890707
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 161
IP  - 2-3
DP  - 1989 Feb 28
TI  - Glucocorticoids and 3,4-methylenedioxymethamphetamine (MDMA)-induced 
      neurotoxicity.
PG  - 181-8
AB  - The present study was carried out in order to explore the role of glucocorticoids 
      in 3,4-methylenedio-xymethamphetamine (MDMA)-induced neurotoxicity of the central 
      serotonergic system. The activity of tryptophan hydroxylase (TPH) was used as an 
      index of this drug-induced neuronal degeneration. One week after a single high 
      dose of MDMA (20 mg/kg), a significant decrease in the enzyme activity was 
      measured in both the frontal cortex and hippocampus. Adrenalectomy (ADX) 
      attenuated or blocked this decrease in TPH activity in the hippocampus but not in 
      the frontal cortex. This protective effect of ADX on hippocampal serotonergic 
      neurons disappeared with concurrent administration of corticosterone (CORT) and 
      MDMA administration. The long-term MDMA-induced decreases in hippocampal 
      serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations were 
      similarly affected by CORT replacement. However, ADX did not alter the short-term 
      decline in hippocampal TPH activity and 5-HT concentrations measured 3 h after a 
      single dose of MDMA (10 mg/kg s.c.). This study suggests that CORT play a role in 
      the development of neurotoxicity induced by MDMA in the hippocampal serotonergic 
      system, but may be less important in other brain structures.
FAU - Johnson, M
AU  - Johnson M
AD  - Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 
      84112.
FAU - Stone, D M
AU  - Stone DM
FAU - Bush, L G
AU  - Bush LG
FAU - Hanson, G R
AU  - Hanson GR
FAU - Gibb, J W
AU  - Gibb JW
LA  - eng
GR  - DA 00869/DA/NIDA NIH HHS/United States
GR  - DA 04221/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amphetamines)
RN  - 0 (Glucocorticoids)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - EC 1.14.16.4 (Tryptophan Hydroxylase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*toxicity
MH  - Adrenalectomy
MH  - Amphetamines/*toxicity
MH  - Animals
MH  - Cerebral Cortex/drug effects/enzymology/metabolism
MH  - Corticosterone/pharmacology
MH  - Glucocorticoids/*physiology
MH  - Hippocampus/drug effects/enzymology/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Nervous System Diseases/*chemically induced
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/metabolism
MH  - Tryptophan Hydroxylase/metabolism
EDAT- 1989/02/28 00:00
MHDA- 1989/02/28 00:01
CRDT- 1989/02/28 00:00
PHST- 1989/02/28 00:00 [pubmed]
PHST- 1989/02/28 00:01 [medline]
PHST- 1989/02/28 00:00 [entrez]
AID - 0014-2999(89)90841-8 [pii]
AID - 10.1016/0014-2999(89)90841-8 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1989 Feb 28;161(2-3):181-8. doi: 10.1016/0014-2999(89)90841-8.