PMID- 24706292
OWN - NLM
STAT- MEDLINE
DCOM- 20150221
LR  - 20140616
IS  - 1097-4547 (Electronic)
IS  - 0360-4012 (Linking)
VI  - 92
IP  - 8
DP  - 2014 Aug
TI  - On the role of 5-HT(1A) receptor gene in behavioral effect of brain-derived 
      neurotrophic factor.
PG  - 1035-43
LID - 10.1002/jnr.23381 [doi]
AB  - Experiments were made on a congenic AKR.CBA-D13Mit76C (76C) mouse strain created 
      by transferring a chromosome 13 fragment containing the 5-HT1A receptor gene from 
      a CBA strain to an AKR background. It was shown that 76C mice differed from AKR 
      mice by decreased 5-HT1A receptor and tryptophan hydroxylase-2 (tph-2) genes 
      expression in the midbrain. Functional activity of 5-HT2A receptors and 5-HT(2A) 
      receptor mRNA levels in the midbrain and hippocampus of 76C mice were decreased 
      compared with AKR mice. Central brain-derived neurotrophic factor (BDNF) 
      administration (300 ng i.c.v.) reduced 5-HT1A and 5-HT(2A) receptor mRNA levels 
      in the frontal cortex and tph-2 mRNA level in the midbrain of AKR mice. However, 
      BDNF failed to produce any effect on the expression of 5-HT(1A) , 5-HT(2A) , and 
      tph-2 genes in 76C mice but decreased functional activity of 5-HT(2A) receptors 
      in 76C mice and increased it in AKR mice. BDNF restored social deficiency in 76C 
      mice but produced asocial behavior (aggressive attacks towards young mice) in AKR 
      mice. The data indicate that a small genetic variation altered the response to 
      BDNF and show an important role of 5-HT(1A) receptor gene in the 5-HT system 
      response to BDNF treatment and in behavioral effects of BDNF.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Naumenko, Vladimir S
AU  - Naumenko VS
AD  - Department of Behavioral Neurogenomics, Institute of Cytology and Genetics, 
      Siberian Division of the Russian Academy of Science, Novosibirsk, Russia.
FAU - Kondaurova, Elena M
AU  - Kondaurova EM
FAU - Bazovkina, Daria V
AU  - Bazovkina DV
FAU - Tsybko, Anton S
AU  - Tsybko AS
FAU - Il'chibaeva, Tatyana V
AU  - Il'chibaeva TV
FAU - Popova, Nina K
AU  - Popova NK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140403
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
SB  - IM
MH  - Aggression/drug effects/physiology
MH  - Animals
MH  - Behavior, Animal/*drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism/*pharmacology
MH  - Hippocampus/drug effects/*metabolism
MH  - Male
MH  - Mesencephalon/drug effects/*metabolism
MH  - Mice
MH  - Mice, Inbred AKR
MH  - Mice, Inbred CBA
MH  - Receptor, Serotonin, 5-HT1A/*genetics/metabolism
MH  - Social Behavior
OTO - NOTNLM
OT  - 5-HT transporter
OT  - 5-HT1A
OT  - 5-HT1A and 5-HT2A receptor functional activity
OT  - 5-HT2A receptor
OT  - BDNF
OT  - aggression
OT  - brain 5-HT system
OT  - congenic mice
OT  - tryptophan hydroxylase-2 genes expression
EDAT- 2014/04/08 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/04/08 06:00
PHST- 2013/11/27 00:00 [received]
PHST- 2014/01/31 00:00 [revised]
PHST- 2014/02/19 00:00 [accepted]
PHST- 2014/04/08 06:00 [entrez]
PHST- 2014/04/08 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - 10.1002/jnr.23381 [doi]
PST - ppublish
SO  - J Neurosci Res. 2014 Aug;92(8):1035-43. doi: 10.1002/jnr.23381. Epub 2014 Apr 3.