PMID- 24707407
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140407
LR  - 20211021
IS  - 2090-5467 (Print)
IS  - 2090-5475 (Electronic)
IS  - 2090-5467 (Linking)
VI  - 2014
DP  - 2014
TI  - Minimally invasive minor salivary gland biopsy for the diagnosis of amyloidosis 
      in a rheumatology clinic.
PG  - 354648
LID - 10.1155/2014/354648 [doi]
LID - 354648
AB  - Background. Systemic amyloidosis is a potentially fatal condition, unless 
      diagnosed and treated before development of irreversible organ damage. 
      Demonstration of amyloid deposits within tissue biopsies is only definitive 
      diagnostic method, which makes appropriate selection of biopsy site essential. 
      Herein, we evaluated efficacy of minimally invasive minor salivary gland biopsy 
      (MSGB) for the diagnosis of amyloidosis. Methods. We analyzed 37 biopsies taken 
      from 35 patients. Suggestive findings for amyloidosis were significant 
      proteinuria, renal impairment, refractory diarrhea, neuropathy, and restrictive 
      cardiomyopathy. Minor salivary gland was the initial biopsy site in all subjects. 
      When MSGB was negative but there was a high suspicion for amyloidosis, a kidney, 
      duodenum, or rectal biopsy was performed for further investigation. Results. Mean 
      age of patients was 45.4 and 21 were female. In 11 patients amyloidosis was 
      diagnosed with MSGB. In overall 18 patients were diagnosed with amyloidosis. 
      Sixteen of them were identified as being of AA type and two were AL type 
      amyloidosis. The sensitivity of minimally invasive MSGB is 61.1% for diagnosing 
      amyloidosis in this study. Conclusion. MSGB is a safe and simple method for the 
      diagnosis of amyloidosis which can be performed in an outpatient setting. We 
      suggest extensive use of this minimally invasive method.
FAU - Mercan, Ridvan
AU  - Mercan R
AD  - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, 
      Gazi University, Ic Hastaliklari ABD, Romatoloji BD, Besevler, 06500 Ankara, 
      Turkey.
FAU - Bitik, Berivan
AU  - Bitik B
AD  - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, 
      Gazi University, Ic Hastaliklari ABD, Romatoloji BD, Besevler, 06500 Ankara, 
      Turkey.
FAU - Tezcan, Mehmet Engin
AU  - Tezcan ME
AUID- ORCID: 0000-0002-1753-4936
AD  - Department of Rheumatology, Kartal Research and Training Hospital, 34890 
      Istanbul, Turkey.
FAU - Kaya, Arif
AU  - Kaya A
AD  - Department of Rheumatology, State Hospital, 20125 Denizli, Turkey.
FAU - Tufan, Abdurrahman
AU  - Tufan A
AD  - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, 
      Gazi University, Ic Hastaliklari ABD, Romatoloji BD, Besevler, 06500 Ankara, 
      Turkey.
FAU - Ozturk, Mehmet Akif
AU  - Ozturk MA
AD  - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, 
      Gazi University, Ic Hastaliklari ABD, Romatoloji BD, Besevler, 06500 Ankara, 
      Turkey.
FAU - Haznedaroglu, Seminur
AU  - Haznedaroglu S
AD  - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, 
      Gazi University, Ic Hastaliklari ABD, Romatoloji BD, Besevler, 06500 Ankara, 
      Turkey.
FAU - Goker, Berna
AU  - Goker B
AD  - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, 
      Gazi University, Ic Hastaliklari ABD, Romatoloji BD, Besevler, 06500 Ankara, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20140223
PL  - Egypt
TA  - ISRN Rheumatol
JT  - ISRN rheumatology
JID - 101570649
PMC - PMC3953425
EDAT- 2014/04/08 06:00
MHDA- 2014/04/08 06:01
PMCR- 2014/02/23
CRDT- 2014/04/08 06:00
PHST- 2013/12/19 00:00 [received]
PHST- 2014/01/15 00:00 [accepted]
PHST- 2014/04/08 06:00 [entrez]
PHST- 2014/04/08 06:00 [pubmed]
PHST- 2014/04/08 06:01 [medline]
PHST- 2014/02/23 00:00 [pmc-release]
AID - 10.1155/2014/354648 [doi]
PST - epublish
SO  - ISRN Rheumatol. 2014 Feb 23;2014:354648. doi: 10.1155/2014/354648. eCollection 
      2014.