PMID- 24707480
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20211021
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2014
DP  - 2014
TI  - Comparing microspheres with different internal phase of polyelectrolyte as local 
      drug delivery system for bone tuberculosis therapy.
PG  - 297808
LID - 10.1155/2014/297808 [doi]
LID - 297808
AB  - We use hydrophobic poly(lactic-co-glycolic) acid (PLGA) to encapsulate 
      hydrophilic ofloxacin to form drug loading microspheres. Hyaluronic acid (HA) and 
      polylysine (Pls) were used as internal phase additives to see their influences on 
      the drug loading and releasing. Double emulsion (water-in-oil-in-water) solvent 
      extraction/evaporation method was used for the purpose. Particle size analysis 
      display that the polyelectrolytes have low impact on the microsphere average size 
      and distribution. Scanning electron microscope (SEM) pictures show the wrinkled 
      surface resulted by the internal microcavity of the microspheres. Microspheres 
      with HA inside have higher drug loading amounts than microspheres with Pls 
      inside. The loading drug amounts of the microspheres increase with the HA amounts 
      inside, while decreasing with the Pls amounts inside. All the polyelectrolytes 
      adding groups have burst release observed in experiments. The microspheres with 
      Pls internal phase have faster release rate than the HA groups. Among the same 
      polyelectrolyte internal phase groups, the release rate increases with the 
      amounts increasing when Pls is inside, while it decreases with the amounts 
      increasing when HA is inside.
FAU - Wu, Gang
AU  - Wu G
AUID- ORCID: 0000-0002-4730-4971
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou 510640, China ; National Engineering Center for Tissue 
      Restoration and Reconstruction, Guangzhou 510006, China.
FAU - Chen, Long
AU  - Chen L
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou 510640, China ; National Engineering Center for Tissue 
      Restoration and Reconstruction, Guangzhou 510006, China.
FAU - Li, Hong
AU  - Li H
AD  - Department of Materials Science and Engineering, Jinan University, Guangzhou 
      510632, China.
FAU - Deng, Chun-Ling
AU  - Deng CL
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou 510640, China ; National Engineering Center for Tissue 
      Restoration and Reconstruction, Guangzhou 510006, China.
FAU - Chen, Xiao-Feng
AU  - Chen XF
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou 510640, China ; National Engineering Center for Tissue 
      Restoration and Reconstruction, Guangzhou 510006, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140223
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Emulsions)
RN  - 0 (Oils)
RN  - 0 (Polymers)
RN  - 0 (Solvents)
RN  - 059QF0KO0R (Water)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 25104-18-1 (Polylysine)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - A4P49JAZ9H (Ofloxacin)
SB  - IM
MH  - Drug Delivery Systems/methods
MH  - Emulsions/chemistry/pharmacology
MH  - Hyaluronic Acid/chemistry
MH  - Lactic Acid/chemistry
MH  - *Microspheres
MH  - Ofloxacin/chemistry/pharmacology
MH  - Oils/chemistry
MH  - Particle Size
MH  - Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polylysine/chemistry
MH  - Polymers/*chemistry/*pharmacology
MH  - Solvents/chemistry
MH  - Tuberculosis, Osteoarticular/*drug therapy
MH  - Water/chemistry
PMC - PMC3950922
EDAT- 2014/04/08 06:00
MHDA- 2015/01/13 06:00
PMCR- 2014/02/23
CRDT- 2014/04/08 06:00
PHST- 2013/11/07 00:00 [received]
PHST- 2013/12/31 00:00 [revised]
PHST- 2014/01/12 00:00 [accepted]
PHST- 2014/04/08 06:00 [entrez]
PHST- 2014/04/08 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
PHST- 2014/02/23 00:00 [pmc-release]
AID - 10.1155/2014/297808 [doi]
PST - ppublish
SO  - Biomed Res Int. 2014;2014:297808. doi: 10.1155/2014/297808. Epub 2014 Feb 23.