PMID- 24707947
OWN - NLM
STAT- MEDLINE
DCOM- 20151007
LR  - 20211203
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 56
IP  - 1
DP  - 2015 Jan
TI  - Genetic markers in a multi-ethnic sample for childhood acute lymphoblastic 
      leukemia risk.
PG  - 169-74
LID - 10.3109/10428194.2014.910662 [doi]
AB  - Genome-wide association studies have identified multiple risk loci for childhood 
      acute lymphoblastic leukemia (ALL), but mostly in European/White populations, 
      despite Hispanics having a greater risk. We re-examined single nucleotide 
      polymorphisms (SNPs) of known associations with childhood ALL and known human 
      leukocyte antigen (HLA) region lymphoma risk markers in a multi-ethnic 
      population. Significant associations were found in two ARID5B variants (rs7089424 
      and rs10821936). We replicated a strong risk association in non-Hispanic White 
      males with rs2395185, a protective marker for lymphoma. Another HLA region 
      marker, rs2647012, showed a risk association among Hispanics only, while a strong 
      protective association was found with rs1048456, a follicular lymphoma risk 
      marker. Our study validated this new case-control sample by confirming genetic 
      markers associated with childhood ALL, and yielded new associations with lymphoma 
      markers. Despite positive results, our study did not provide any clues as to why 
      Hispanics have a higher susceptibility to childhood leukemia, suggesting that 
      environmental factors may have a strong contribution.
FAU - Kennedy, Amy E
AU  - Kennedy AE
AD  - Department of Epidemiology, Robert Stempel College of Public Health and Social 
      Work, Florida International University , Miami, FL , USA.
FAU - Kamdar, Kala Y
AU  - Kamdar KY
FAU - Lupo, Philip J
AU  - Lupo PJ
FAU - Okcu, M Fatih
AU  - Okcu MF
FAU - Scheurer, Michael E
AU  - Scheurer ME
FAU - Dorak, M Tevfik
AU  - Dorak MT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140616
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Ethnicity/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Loci
MH  - *Genetic Markers
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Male
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
OTO - NOTNLM
OT  - Genetic associations
OT  - childhood acute lymphoblastic leukemia
OT  - genetic predisposition to disease
EDAT- 2014/04/09 06:00
MHDA- 2015/10/08 06:00
CRDT- 2014/04/09 06:00
PHST- 2014/04/09 06:00 [entrez]
PHST- 2014/04/09 06:00 [pubmed]
PHST- 2015/10/08 06:00 [medline]
AID - 10.3109/10428194.2014.910662 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2015 Jan;56(1):169-74. doi: 10.3109/10428194.2014.910662. Epub 
      2014 Jun 16.