PMID- 24709160
OWN - NLM
STAT- MEDLINE
DCOM- 20150331
LR  - 20220408
IS  - 1528-8447 (Electronic)
IS  - 1526-5900 (Linking)
VI  - 15
IP  - 8
DP  - 2014 Aug
TI  - Local infiltration analgesia for postoperative pain after hip arthroplasty: a 
      systematic review and meta-analysis.
PG  - 781-99
LID - S1526-5900(14)00651-8 [pii]
LID - 10.1016/j.jpain.2014.03.002 [doi]
AB  - Postoperative pain after hip arthroplasty (HA) is very common and severe. 
      Currently, use of routine analgesic methods is often accompanied by adverse 
      events (AEs). Local infiltration analgesia (LIA) for controlling pain has been a 
      therapeutic option in many surgical procedures. However, its analgesic efficacy 
      in HA and its safety remain unclear. Data from 9 randomized controlled trials, 
      involving 760 participants, comparing the effect of LIA with that of placebo 
      infiltration or no infiltration on patients undergoing HA were retrieved from an 
      electronic database, and the pain scores, analgesic consumption, and AEs were 
      analyzed. Effects were summarized using weighted mean differences, standardized 
      mean differences, or odds ratio with fixed or random effect models. There was 
      strong evidence of an association between LIA and reduced pain scores at 4 hours 
      at rest (P < .00001) and with motion (P < .00001), 6 hours with motion (P = .02), 
      and 24 hours at rest (P = .01), and decreased analgesic consumption during 0 to 
      24 hours (P = .001) after HA. These analgesic efficacies for LIA were not 
      accompanied by any increased risk for AEs. However, the current meta-analysis did 
      not reveal any associations between LIA and the reduced pain scores or analgesic 
      consumption at other time points. The results suggest that LIA can be used for 
      controlling pain after HA because of its efficacy in reducing pain scores and 
      thus can reduce analgesic consumption on the first day without increased risk of 
      AEs. PERSPECTIVE: This is the first pooled database meta-analysis to assess the 
      analgesic effects and safety of LIA in controlling pain after HA. The derived 
      information offers direct evidence that LIA can be used for patients undergoing 
      HA because of its ability to reduce pain scores and analgesic consumption without 
      any additional AEs.
CI  - Copyright (c) 2014 American Pain Society. Published by Elsevier Inc. All rights 
      reserved.
FAU - Yin, Jun-Bin
AU  - Yin JB
AD  - Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain 
      Research Centre, Preclinical School of Medicine, Fourth Military Medical 
      University, Xi'an, PR China.
FAU - Cui, Guang-Bin
AU  - Cui GB
AD  - Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain 
      Research Centre, Preclinical School of Medicine, Fourth Military Medical 
      University, Xi'an, PR China; Department of Radiology, Tangdu Hospital, Fourth 
      Military Medical University, Xi'an, PR China.
FAU - Mi, Ming-Shan
AU  - Mi MS
AD  - Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain 
      Research Centre, Preclinical School of Medicine, Fourth Military Medical 
      University, Xi'an, PR China; Department of Orthopaedics, Affiliated Hospital of 
      Qinghai University, Xining, PR China.
FAU - Du, Yu-Xia
AU  - Du YX
AD  - Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain 
      Research Centre, Preclinical School of Medicine, Fourth Military Medical 
      University, Xi'an, PR China; Dental Department of Qinghai Provincial People's 
      Hospital, Xining, PR China.
FAU - Wu, Sheng-Xi
AU  - Wu SX
AD  - Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain 
      Research Centre, Preclinical School of Medicine, Fourth Military Medical 
      University, Xi'an, PR China.
FAU - Li, Yun-Qing
AU  - Li YQ
AD  - Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain 
      Research Centre, Preclinical School of Medicine, Fourth Military Medical 
      University, Xi'an, PR China.
FAU - Wang, Wen
AU  - Wang W
AD  - Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain 
      Research Centre, Preclinical School of Medicine, Fourth Military Medical 
      University, Xi'an, PR China. Electronic address: wangwen@fmmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20140405
PL  - United States
TA  - J Pain
JT  - The journal of pain
JID - 100898657
RN  - RA33EAC7KY (Fenoprofen)
SB  - IM
MH  - Analgesia/*methods
MH  - Arthroplasty/*adverse effects
MH  - Drug Administration Routes
MH  - Fenoprofen/*therapeutic use
MH  - Hip/surgery
MH  - Humans
MH  - Pain, Postoperative/*drug therapy/etiology
OTO - NOTNLM
OT  - Local infiltration analgesia
OT  - hip arthroplasty
OT  - meta-analysis
OT  - postoperative pain
OT  - review
EDAT- 2014/04/09 06:00
MHDA- 2015/04/01 06:00
CRDT- 2014/04/09 06:00
PHST- 2013/12/30 00:00 [received]
PHST- 2014/02/08 00:00 [revised]
PHST- 2014/03/06 00:00 [accepted]
PHST- 2014/04/09 06:00 [entrez]
PHST- 2014/04/09 06:00 [pubmed]
PHST- 2015/04/01 06:00 [medline]
AID - S1526-5900(14)00651-8 [pii]
AID - 10.1016/j.jpain.2014.03.002 [doi]
PST - ppublish
SO  - J Pain. 2014 Aug;15(8):781-99. doi: 10.1016/j.jpain.2014.03.002. Epub 2014 Apr 5.