PMID- 24709243
OWN - NLM
STAT- MEDLINE
DCOM- 20150413
LR  - 20140408
IS  - 1681-7168 (Electronic)
IS  - 1022-386X (Linking)
VI  - 24
IP  - 4
DP  - 2014 Apr
TI  - Possible role of brain-derived neurotrophic factor (BDNF) in autism spectrum 
      disorder: current status.
PG  - 274-8
AB  - Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of 
      survival-promoting molecules, plays a vital role in the growth, development, 
      maintenance, and function of several neuronal systems. The purpose of this review 
      is to document the support for the involvement of this molecule in the 
      maintenance of normal cognitive, emotional functioning, and to outline recent 
      developments in the content of Autism spectrum disorder (ASD). Current and future 
      treatment development can be guided by developing understanding of this 
      molecule's actions in the brain and the ways the expression of BDNF can be 
      planned. Over the years, research findings suggested a critical role played by 
      BDNF in the development of autism including increased serum concentrations of 
      BDNF in children with autism and identification of different forms of BDNF in 
      families of autistic individuals.
FAU - Halepoto, Dost Muhammad
AU  - Halepoto DM
AD  - Department of Physiology, Faculty of Medicine, Autism Research and Treatment 
      Center, King Saud University, Riyadh, Saudi Arabia.
FAU - Bashir, Shahid
AU  - Bashir S
AD  - Department of Physiology, Faculty of Medicine, Autism Research and Treatment 
      Center, King Saud University, Riyadh, Saudi Arabia.
FAU - A L-Ayadhi, Laila
AU  - A L-Ayadhi L
AD  - Department of Physiology, Faculty of Medicine, Autism Research and Treatment 
      Center, King Saud University, Riyadh, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child Development Disorders, Pervasive/blood/*etiology
MH  - Cognition/physiology
MH  - Humans
EDAT- 2014/04/09 06:00
MHDA- 2015/04/14 06:00
CRDT- 2014/04/09 06:00
PHST- 2013/04/11 00:00 [received]
PHST- 2013/09/08 00:00 [accepted]
PHST- 2014/04/09 06:00 [entrez]
PHST- 2014/04/09 06:00 [pubmed]
PHST- 2015/04/14 06:00 [medline]
AID - 040579197 [pii]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2014 Apr;24(4):274-8.