PMID- 24709918
OWN - NLM
STAT- MEDLINE
DCOM- 20150220
LR  - 20211021
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 25
IP  - 10
DP  - 2014 Jul 9
TI  - Significantly decreased mRNA levels of BDNF and MEK1 genes in treatment-resistant 
      depression.
PG  - 753-5
LID - 10.1097/WNR.0000000000000165 [doi]
AB  - The aim of the current study was to investigate whether the levels of mRNA 
      expression of brain-derived neurotrophin factor (BDNF) and a related gene MEK1 
      were more obviously decreased in treatment-resistant depression (TRD). In total, 
      50 patients with major depressive disorder (including 26 with TRD and 24 with 
      treatment-responsive depression) and 48 healthy controls were enrolled. BDNF and 
      MEK1 mRNA levels in blood samples from all patients and controls were measured 
      using reverse transcriptase-PCR. BDNF and MEK1 mRNA levels were significantly 
      reduced in patients with major depressive disorder when compared with healthy 
      controls (BDNF: P<0.01; MEK1: P<0.001), as well as among treatment-resistant 
      depressive patients as compared with treatment-responsive depressive patients 
      (BDNF: P<0.001; MEK1: P<0.01). Our findings support the hypothesis that BDNF and 
      MEK1 mRNA expression levels are more obviously decreased in patients with TRD.
FAU - Hong, Wu
AU  - Hong W
AD  - aShanghai Mental Health Center, Division of Mood Disorders, Shanghai Jiao Tong 
      University School of Medicine, Shanghai bKey Laboratory of Animal Models and 
      Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, 
      Kunming Institute of Zoology, Kunming, China cDepartment of Epidemiology and 
      Biostatistics, Case Western Reserve University School of Medicine, Cleveland, 
      Ohio, USA.
FAU - Fan, Jinbo
AU  - Fan J
FAU - Yuan, Chengmei
AU  - Yuan C
FAU - Zhang, Chen
AU  - Zhang C
FAU - Hu, Yingyan
AU  - Hu Y
FAU - Peng, Daihui
AU  - Peng D
FAU - Wang, Yong
AU  - Wang Y
FAU - Huang, Jia
AU  - Huang J
FAU - Li, Zezhi
AU  - Li Z
FAU - Yu, Shunying
AU  - Yu S
FAU - Liu, Xiaohua
AU  - Liu X
FAU - Wu, Zhiguo
AU  - Wu Z
FAU - Chen, Jun
AU  - Chen J
FAU - Yi, Zhenghui
AU  - Yi Z
FAU - Xu, Lin
AU  - Xu L
FAU - Fang, Yiru
AU  - Fang Y
LA  - eng
GR  - KL2 RR024990/RR/NCRR NIH HHS/United States
GR  - UL1 TR000439/TR/NCATS NIH HHS/United States
GR  - KL2RR024990/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 1)
RN  - EC 2.7.12.2 (MAP2K1 protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depressive Disorder, Major/*genetics
MH  - Depressive Disorder, Treatment-Resistant/*genetics
MH  - Female
MH  - Humans
MH  - MAP Kinase Kinase 1/*genetics
MH  - Male
MH  - Middle Aged
MH  - RNA, Messenger/metabolism
PMC - PMC4465888
MID - NIHMS697708
COIS- Conflicts of interest: There are no conflicts of interest.
EDAT- 2014/04/09 06:00
MHDA- 2015/02/24 06:00
PMCR- 2015/06/14
CRDT- 2014/04/09 06:00
PHST- 2014/04/09 06:00 [entrez]
PHST- 2014/04/09 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
PHST- 2015/06/14 00:00 [pmc-release]
AID - 10.1097/WNR.0000000000000165 [doi]
PST - ppublish
SO  - Neuroreport. 2014 Jul 9;25(10):753-5. doi: 10.1097/WNR.0000000000000165.