PMID- 24710074
OWN - NLM
STAT- MEDLINE
DCOM- 20150514
LR  - 20140908
IS  - 1460-4744 (Electronic)
IS  - 0306-0012 (Linking)
VI  - 43
IP  - 19
DP  - 2014 Oct 7
TI  - Cholesterol and metal ions in Alzheimer's disease.
PG  - 6672-82
LID - 10.1039/c4cs00005f [doi]
AB  - Cholesterol and metal ions have been suggested to be associated with the onset 
      and progression of Alzheimer's disease (AD). Moreover, recent findings have 
      demonstrated a potential interconnection between these two factors. For example, 
      (a) cholesterol has been shown to be misregulated in AD-afflicted brains, and the 
      aberrant activity of proteins (particularly, apolipoprotein E (ApoE) and 
      3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)) has been linked 
      to cholesterol-related AD exacerbation; (b) dyshomeostasis of metal ions 
      associated with misfolded proteins (i.e., amyloid-beta (Abeta) aggregates) found in the 
      brains of AD patients is shown to promote oxidative stress leading to the 
      malfunction of multiple proteins, including cytochrome c oxidase (CcO), and Cu/Zn 
      superoxide dismutase (SOD1); (c) metal ion misregulation has also been observed 
      to disrupt the activity of proteins (e.g., HMGR, low-density lipoproteins (LDL)), 
      required for cholesterol production and regulation. Herein, we briefly discuss 
      the potential involvement of cholesterol and metal ions in AD neuropathogenesis 
      in both individual and interrelated manners.
FAU - Lee, Hyuck Jin
AU  - Lee HJ
AD  - Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, 
      USA.
FAU - Korshavn, Kyle J
AU  - Korshavn KJ
FAU - Kochi, Akiko
AU  - Kochi A
FAU - Derrick, Jeffrey S
AU  - Derrick JS
FAU - Lim, Mi Hee
AU  - Lim MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20140408
PL  - England
TA  - Chem Soc Rev
JT  - Chemical Society reviews
JID - 0335405
RN  - 0 (Apolipoproteins E)
RN  - 0 (Metals)
RN  - 0 (Reactive Oxygen Species)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.1.1.34 (Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent)
SB  - IM
MH  - Alzheimer Disease/metabolism/*pathology
MH  - Apolipoproteins E/metabolism
MH  - Brain/metabolism
MH  - Cholesterol/chemistry/*metabolism
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent/metabolism
MH  - Metals/chemistry/*metabolism
MH  - Reactive Oxygen Species/metabolism
EDAT- 2014/04/09 06:00
MHDA- 2015/05/15 06:00
CRDT- 2014/04/09 06:00
PHST- 2014/04/09 06:00 [entrez]
PHST- 2014/04/09 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
AID - 10.1039/c4cs00005f [doi]
PST - ppublish
SO  - Chem Soc Rev. 2014 Oct 7;43(19):6672-82. doi: 10.1039/c4cs00005f. Epub 2014 Apr 
      8.