PMID- 24710417
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140408
LR  - 20211021
IS  - 2073-4409 (Print)
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 1
IP  - 2
DP  - 2012 May 10
TI  - Role of ELISPOT Assays in Risk Assessment Pre- and Post-Kidney Transplantation.
PG  - 100-10
LID - 10.3390/cells1020100 [doi]
AB  - Immunologic risk in kidney transplantation is typically minimized by avoiding, or 
      at least limiting, the potential of donor specific humoral responses by testing 
      for the presence of donor-specific antibodies (DSA). Additionally, selecting 
      donor and recipient pairs with the least number of human leukocyte antigen (HLA) 
      mismatches has been shown to play a role in transplant outcome. However, numerous 
      other factors may play a role in the success of transplant outcome and patient 
      health. Specifically, the use of T-cell allospecific ELISPOT assays have helped 
      elucidate the role of pre-formed cellular responses as additional factors in 
      post-transplant outcome. In this review, we will evaluate numerous uses of 
      ELISPOT assays to assess the pre- and post-transplant immunologic risk of 
      rejection episodes, graft survival and even viral susceptibility as well as the 
      utility of ELISPOT assays in monitoring tolerance and withdrawal of 
      immunosuppressive medications following kidney transplantation.
FAU - Zitzner, Jennifer R
AU  - Zitzner JR
AD  - Comprehensive Transplant Center Feinberg School of Medicine, Northwestern 
      University, 303 E Chicago Ave., Tarry Building Suite 11-703, Chicago, IL 
      60611-3008, USA. j-wehner@northwestern.edu.
FAU - Tambur, Anat R
AU  - Tambur AR
AD  - Comprehensive Transplant Center Feinberg School of Medicine, Northwestern 
      University, 303 E Chicago Ave., Tarry Building Suite 11-703, Chicago, IL 
      60611-3008, USA. a-tambur@northwestern.edu.
LA  - eng
PT  - Journal Article
DEP - 20120510
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
PMC - PMC3901086
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
PMCR- 2012/06/01
CRDT- 2014/04/09 06:00
PHST- 2012/03/23 00:00 [received]
PHST- 2012/04/30 00:00 [revised]
PHST- 2012/05/07 00:00 [accepted]
PHST- 2014/04/09 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - cells1020100 [pii]
AID - cells-01-00100 [pii]
AID - 10.3390/cells1020100 [doi]
PST - epublish
SO  - Cells. 2012 May 10;1(2):100-10. doi: 10.3390/cells1020100.