PMID- 24710630
OWN - NLM
STAT- MEDLINE
DCOM- 20160113
LR  - 20211021
IS  - 1591-9528 (Electronic)
IS  - 1591-8890 (Linking)
VI  - 15
IP  - 2
DP  - 2015 May
TI  - Elevated serum level of IL-27 and VEGF in patients with ankylosing spondylitis 
      and associate with disease activity.
PG  - 227-31
LID - 10.1007/s10238-014-0281-x [doi]
AB  - Interleukin (IL)-27 is an IL-12 family cytokine and exerts a critical role in 
      immune regulation in the context of infection, autoimmunity, and angiogenesis. In 
      this study, we aimed to investigate the possible pathophysiological role of IL-27 
      and vascular endothelial growth factor (VEGF) in ankylosing spondylitis (AS). One 
      hundred and forty AS patients and 90 healthy controls were included in the 
      current study. The levels of IL-27 and VEGF in serum and synovial fluid (SF) 
      samples were measured by enzyme-linked immunosorbent assay. Erythrocyte 
      sedimentation rate, C-reactive protein, and human leukocyte antigen (HLA)-B27 
      were measured by standard laboratory techniques. Disease activity in AS was 
      scored with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Hip 
      involvement, peripheral arthritis, and eye involvement were also recorded. The 
      serum levels of IL-27 were remarkably higher in AS patients than healthy groups 
      and significantly correlated with serum levels of VEGF. Furthermore, the serum 
      levels of IL-27 were correlated with BASDAI independent of other markers of 
      inflammation. Elevated serum levels of IL-27 and VEGF were detected in AS 
      patients with peripheral arthritis and HLA-B27 positive. The SF levels of IL-27 
      and VEGF were significantly higher than serum levels in AS patients with 
      peripheral arthritis. By contrast, levels of IL-27 and VEGF were not increased in 
      AS patients with hip involvement and eye involvement. IL-27 may regulate the 
      immunological or inflammatory process of AS.
FAU - Lin, Tian-Tian
AU  - Lin TT
AD  - Department of Rheumatology and Immunology, The First Affiliated Hospital of China 
      Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, 
      People's Republic of China.
FAU - Lu, Jing
AU  - Lu J
FAU - Qi, Chen-Yue
AU  - Qi CY
FAU - Yuan, Lin
AU  - Yuan L
FAU - Li, Xiao-Lin
AU  - Li XL
FAU - Xia, Li-Ping
AU  - Xia LP
FAU - Shen, Hui
AU  - Shen H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140408
PL  - Italy
TA  - Clin Exp Med
JT  - Clinical and experimental medicine
JID - 100973405
RN  - 0 (Biomarkers)
RN  - 0 (Interleukins)
RN  - 0 (MYDGF protein, human)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Adult
MH  - Biomarkers/*blood
MH  - Cohort Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interleukins/*blood
MH  - Male
MH  - Serum/chemistry
MH  - Severity of Illness Index
MH  - Spondylitis, Ankylosing/*pathology
MH  - Synovial Fluid/chemistry
MH  - Vascular Endothelial Growth Factor A/*blood
EDAT- 2014/04/09 06:00
MHDA- 2016/01/14 06:00
CRDT- 2014/04/09 06:00
PHST- 2013/11/27 00:00 [received]
PHST- 2014/03/25 00:00 [accepted]
PHST- 2014/04/09 06:00 [entrez]
PHST- 2014/04/09 06:00 [pubmed]
PHST- 2016/01/14 06:00 [medline]
AID - 10.1007/s10238-014-0281-x [doi]
PST - ppublish
SO  - Clin Exp Med. 2015 May;15(2):227-31. doi: 10.1007/s10238-014-0281-x. Epub 2014 
      Apr 8.