PMID- 24710774
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20151119
IS  - 1534-4681 (Electronic)
IS  - 1068-9265 (Linking)
VI  - 21
IP  - 8
DP  - 2014 Aug
TI  - Minimal clinically important differences in quality of life scores of oral cavity 
      and oropharynx cancer patients.
PG  - 2773-81
LID - 10.1245/s10434-014-3656-z [doi]
AB  - BACKGROUND: The minimal clinically important difference (MCID) is defined as the 
      smallest difference in quality of life (QOL) that patients perceive as beneficial 
      and that mandates a change in management. We aimed to determine the MCID among 
      patients with oral cavity and oropharyngeal cancer and to identify domains that 
      are significantly affected during treatment. METHODS: The cohort consisted of 
      1,011 patients analyzed by a metaanalysis according to the Preferred Reporting 
      Items for Systematic Reviews and Meta-Analyses statement. MCID values for the 
      University of Washington Quality of Life Questionnaire (UW-QOLQ) and European 
      Organization for Research and Treatment of Cancer Quality of Life Questionnaire 
      (EORTC C-30) and Head and Neck-35 questionnaires were calculated by using the 
      distribution-based method. RESULTS: The mean MCID for Global QOL was 13.07 points 
      for the UW-QOLQ and 9.43 in the EORTC C-30 questionnaire. High consistency in the 
      MCID values was found between the two questionnaires examined. Heat map analysis 
      indicated a clinically significant improvement in head and neck-associated 
      domains and in domains associated with general cancer treatment 1 year or more 
      after treatment relative to 3 months after treatment (p < 0.001 and p = 0.016, 
      respectively). In contrast, improvement in general and functional domains was not 
      evident 1 year or more after treatment (p = 0.69). CONCLUSIONS: This study 
      suggests benchmark values for MCID and variation in QOL scores of oral and 
      oropharyngeal cancer patients after treatment. Improvement in head and neck- and 
      general cancer-associated domains may not be translated into a general and 
      functional improvement during the first year of recovery.
FAU - Binenbaum, Yoav
AU  - Binenbaum Y
AD  - Department of Otolaryngology Head and Neck Surgery, The Technion, Israel 
      Institute of Technology, Haifa, Israel.
FAU - Amit, Moran
AU  - Amit M
FAU - Billan, Salem
AU  - Billan S
FAU - Cohen, Jacob T
AU  - Cohen JT
FAU - Gil, Ziv
AU  - Gil Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140408
PL  - United States
TA  - Ann Surg Oncol
JT  - Annals of surgical oncology
JID - 9420840
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Meta-Analysis as Topic
MH  - Middle Aged
MH  - Mouth Neoplasms/*psychology/*therapy
MH  - Oropharyngeal Neoplasms/*psychology/*therapy
MH  - Prognosis
MH  - *Quality of Life
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2014/04/09 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/04/09 06:00
PHST- 2013/10/31 00:00 [received]
PHST- 2014/04/09 06:00 [entrez]
PHST- 2014/04/09 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.1245/s10434-014-3656-z [doi]
PST - ppublish
SO  - Ann Surg Oncol. 2014 Aug;21(8):2773-81. doi: 10.1245/s10434-014-3656-z. Epub 2014 
      Apr 8.