PMID- 24711033
OWN - NLM
STAT- MEDLINE
DCOM- 20140605
LR  - 20140408
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 31
IP  - 2
DP  - 2014 Apr
TI  - [Clinical feature and cytogenetic analysis of 80 patients with acute monocytic 
      leukemia].
PG  - 206-9
LID - 10.3760/cma.j.issn.1003-9406.2014.02.017 [doi]
AB  - OBJECTIVE: To explore the relationship between cytogenetic and clinical features 
      and prognosis for patients with acute monocytic leukemia (M5 type). METHODS: 
      Chromosome samples were prepared by direct culture of bone marrow for 24 hours. 
      Karyotypes of 80 patients with M5 were analyzed by R banding. Rearrangement of 
      MLL gene and deletion of P53 gene were detected by fluorescence in situ 
      hybridization (FISH). RESULTS: Forty-three patients (53.75%) were found to have 
      abnormal karyotypes, which included 23 patients with abnormalities of chromosome 
      11 and 20 with other chromosomal abnormalities. Twenty-four patients had MLL gene 
      rearrangements and 17 had P53 gene deletion. CONCLUSION: 11q23 has been the most 
      common chromosomal abnormality among patients with M5, which is associated with 
      poor prognosis. The frequency of P53 gene deletion in patients with genetic 
      abnormalities were significantly higher than those with normal karyotypes (P < 
      0.05).
FAU - Cen, Ling
AU  - Cen L
AD  - Department of Hematology, Changzhou Second People's Hospital Affiliated to 
      Nanjing Medical University, Changzhou, Jiangsu 213003, P. R. China. 
      zhoumin@medmail.com.cn.
FAU - Jiang, Yu
AU  - Jiang Y
FAU - Chen, Tao
AU  - Chen T
FAU - Zhang, Yan
AU  - Zhang Y
FAU - Zhou, Min
AU  - Zhou M
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Female
MH  - Genes, p53
MH  - Humans
MH  - Leukemia, Monocytic, Acute/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 2014/04/09 06:00
MHDA- 2014/06/06 06:00
CRDT- 2014/04/09 06:00
PHST- 2014/04/09 06:00 [entrez]
PHST- 2014/04/09 06:00 [pubmed]
PHST- 2014/06/06 06:00 [medline]
AID - 940631044 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2014.02.017 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2014 Apr;31(2):206-9. doi: 
      10.3760/cma.j.issn.1003-9406.2014.02.017.