PMID- 24711890
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140408
LR  - 20240410
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 17
IP  - 2
DP  - 2014 Feb
TI  - The efficacy and prophylactic characteristics of omega-3 fatty acids in 
      experimental gingivitis in rats.
PG  - 87-92
AB  - OBJECTIVE(S): Gingivitis is an inflammatory disease that affects tooth-supporting 
      tissues and is caused by a microbe-immune response. The aim of this study was to 
      evaluate the effects of omega-3 fatty acids on immune system regulation and the 
      prevention and treatment of gingivitis using an animal model. MATERIALS AND 
      METHODS: Gingival inflammation was induced by lipopolysaccharide (LPS) injection. 
      Forty adult male rats were divided into four equal groups: 1. Negative control 
      group (sterile saline was injected into gingival tissue followed by oral gavage 
      with saline); 2. Positive control group (LPS injection was followed by oral 
      gavage with saline); 3. Treatment group (LPS injection was followed by oral 
      gavage with omega-3); 4. Prophylactic group (oral gavage with omega-3 was 
      followed by LPS injection). After 24 days, the rats were sacrificed and 
      histological tissue samples were randomly evaluated for the inflammatory tissue 
      changes. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels were 
      measured by ELISA. RESULTS: The levels of IL-1beta and TNF-alpha in the prophylactic 
      group and the level of TNF-alpha in the treatment group were significantly lower than 
      those in the positive control group (P<0.05). The severity of inflammation was 
      normal, slight, moderate, and severe in the negative control group, prophylactic 
      group, treatment group, and positive control group, respectively. ANOVA was used 
      for the statistical analyses, with P<0.05 regarded as significant. CONCLUSION: 
      Prior consumption of omega-3 fatty acids is effective in reducing inflammation in 
      induced rat gingivitis, resulting in a decreased level of biomarkers and fewer 
      destructive effects.
FAU - Araghizadeh, Nasrin
AU  - Araghizadeh N
AD  - Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Paknejad, Mojgan
AU  - Paknejad M
AD  - Department of Periodontology, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Alaeddini, Mojgan
AU  - Alaeddini M
AD  - Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Minaii, Bagher
AU  - Minaii B
AD  - Department of Histology, Faculty of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Abdollahi, Mohammad
AU  - Abdollahi M
AD  - Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Khorasanie, Reza
AU  - Khorasanie R
AD  - Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran 
      University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC3976744
OTO - NOTNLM
OT  - Cytokines
OT  - Gingival diseases
OT  - Histology
OT  - Omega-3
OT  - Rat
EDAT- 2014/04/09 06:00
MHDA- 2014/04/09 06:01
PMCR- 2014/02/01
CRDT- 2014/04/09 06:00
PHST- 2013/06/13 00:00 [received]
PHST- 2013/11/14 00:00 [accepted]
PHST- 2014/04/09 06:00 [entrez]
PHST- 2014/04/09 06:00 [pubmed]
PHST- 2014/04/09 06:01 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - ijbms-17-087 [pii]
PST - ppublish
SO  - Iran J Basic Med Sci. 2014 Feb;17(2):87-92.