PMID- 24713151
OWN - NLM
STAT- MEDLINE
DCOM- 20141216
LR  - 20191210
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 268
DP  - 2014 Jul 15
TI  - Fingolimod increases brain-derived neurotrophic factor levels and ameliorates 
      amyloid beta-induced memory impairment.
PG  - 88-93
LID - S0166-4328(14)00212-5 [pii]
LID - 10.1016/j.bbr.2014.03.046 [doi]
AB  - Alzheimer's disease is a progressive neurodegenerative disorder. Amyloid beta, a 
      neurotoxic protein, causes disruption of hippocampal synaptic plasticity, and 
      induces cognitive impairment in Alzheimer's disease. We previously revealed that 
      fingolimod, a new oral immunosuppressant used to treat multiple sclerosis, 
      ameliorates oligomeric amyloid beta-induced neuronal damage via up-regulation of 
      neuronal brain-derived neurotrophic factor (BDNF). Here, we showed that oral 
      administration of fingolimod ameliorated the impairment in object recognition 
      memory and associative learning in mice injected with amyloid beta. This effect was 
      associated with restoration of normal BDNF expression levels in the cerebral 
      cortices and hippocampi, suggesting that neuroprotection was mediated by 
      up-regulation of neuronal BDNF levels. Therefore, fingolimod may provide 
      therapeutic effects in patients with Alzheimer's disease.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Fukumoto, Kazuya
AU  - Fukumoto K
AD  - Futuristic Environmental Simulation Center, Research Institute of Environmental 
      Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
FAU - Mizoguchi, Hiroyuki
AU  - Mizoguchi H
AD  - Futuristic Environmental Simulation Center, Research Institute of Environmental 
      Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan. 
      Electronic address: h-mizo@riem.nagoya-u.ac.jp.
FAU - Takeuchi, Hideyuki
AU  - Takeuchi H
AD  - Department of Neuroimmunology, Research Institute of Environmental Medicine, 
      Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
FAU - Horiuchi, Hiroshi
AU  - Horiuchi H
AD  - Department of Neuroimmunology, Research Institute of Environmental Medicine, 
      Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
FAU - Kawanokuchi, Jun
AU  - Kawanokuchi J
AD  - Department of Neuroimmunology, Research Institute of Environmental Medicine, 
      Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
FAU - Jin, Shijie
AU  - Jin S
AD  - Department of Neuroimmunology, Research Institute of Environmental Medicine, 
      Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
FAU - Mizuno, Tetsuya
AU  - Mizuno T
AD  - Department of Neuroimmunology, Research Institute of Environmental Medicine, 
      Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
FAU - Suzumura, Akio
AU  - Suzumura A
AD  - Department of Neuroimmunology, Research Institute of Environmental Medicine, 
      Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140405
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Peptide Fragments)
RN  - 0 (Propylene Glycols)
RN  - 0 (amyloid beta-protein (1-42))
RN  - G926EC510T (Fingolimod Hydrochloride)
RN  - NGZ37HRE42 (Sphingosine)
SB  - IM
MH  - Alzheimer Disease
MH  - Amyloid beta-Peptides/*toxicity
MH  - Animals
MH  - Association Learning/drug effects/physiology
MH  - Brain/*drug effects/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebral Cortex/drug effects/physiopathology
MH  - Exploratory Behavior/drug effects/physiology
MH  - Fingolimod Hydrochloride
MH  - Hippocampus/drug effects/physiopathology
MH  - Male
MH  - Memory Disorders/*drug therapy/etiology/physiopathology
MH  - Mice, Inbred C57BL
MH  - Neuroprotective Agents/*pharmacology
MH  - Peptide Fragments/*toxicity
MH  - Propylene Glycols/*pharmacology
MH  - Recognition, Psychology/drug effects/physiology
MH  - Sphingosine/*analogs & derivatives/pharmacology
MH  - Up-Regulation
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Amyloid beta
OT  - Brain-derived neurotrophic factor
OT  - Fingolimod
EDAT- 2014/04/10 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/04/10 06:00
PHST- 2014/01/07 00:00 [received]
PHST- 2014/03/26 00:00 [revised]
PHST- 2014/03/31 00:00 [accepted]
PHST- 2014/04/10 06:00 [entrez]
PHST- 2014/04/10 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - S0166-4328(14)00212-5 [pii]
AID - 10.1016/j.bbr.2014.03.046 [doi]
PST - ppublish
SO  - Behav Brain Res. 2014 Jul 15;268:88-93. doi: 10.1016/j.bbr.2014.03.046. Epub 2014 
      Apr 5.