PMID- 24713358
OWN - NLM
STAT- MEDLINE
DCOM- 20150402
LR  - 20221207
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 217
IP  - 3
DP  - 2014 Jul 30
TI  - Sex-specific association of brain-derived neurotrophic factor (BDNF) Val66Met 
      polymorphism and plasma BDNF with attention-deficit/hyperactivity disorder in a 
      drug-naive Han Chinese sample.
PG  - 191-7
LID - S0165-1781(14)00213-3 [pii]
LID - 10.1016/j.psychres.2014.03.011 [doi]
AB  - A functional polymorphism of the brain derived neurotrophic factor gene (BDNF) 
      (Val66Met) has been suggested to be involved in the pathogenesis of 
      attention-deficit/hyperactivity disorder (ADHD). It also has an impact on 
      peripheral BDNF levels in psychiatric disorders. This study examined the 
      association of Val66Met with plasma BDNF level of ADHD in Han Chinese children 
      (170 medication - naive ADHD patients and 155 unaffected controls, aged 6-16 
      years). The Val allele was showed a higher frequency in females with ADHD (n=84) 
      than controls (P=0.029) from the case-control association study. The analysis of 
      covariance (ANCOVA) indicated that the mean plasma BDNF levels of ADHD patients 
      were significantly higher than that of controls (P=0.001). We performed both 
      total sample and sex stratified analyses to investigate the effect of Val66Met 
      genotype on the plasma BDNF levels, but only a trend of association was found in 
      females with ADHD (n=84), with a tendency of lower plasma BDNF level in Val 
      allele carriers than Met/Met genotype carriers (P=0.071). Our results suggested a 
      sex-specific association between BDNF and ADHD. Furthermore, there was a possible 
      sex-specific relationship between the BDNF Val66Met genotype and plasma BDNF 
      levels. However, further studies are required to elucidate the role of BDNF in 
      ADHD.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Li, Haimei
AU  - Li H
AD  - Peking University Sixth Hospital/Institute of Mental Health, Beijing 100191, 
      China; Key Laboratory of Mental Health, Ministry of Health, Peking University, 
      Beijing 100191, China.
FAU - Liu, Lu
AU  - Liu L
AD  - Peking University Sixth Hospital/Institute of Mental Health, Beijing 100191, 
      China; Key Laboratory of Mental Health, Ministry of Health, Peking University, 
      Beijing 100191, China.
FAU - Tang, Yilang
AU  - Tang Y
AD  - Department of Psychiatry and Behavioral Sciences, Emory University School of 
      Medicine, Atlanta, GA, USA.
FAU - Ji, Ning
AU  - Ji N
AD  - Peking University Sixth Hospital/Institute of Mental Health, Beijing 100191, 
      China; Key Laboratory of Mental Health, Ministry of Health, Peking University, 
      Beijing 100191, China.
FAU - Yang, Li
AU  - Yang L
AD  - Peking University Sixth Hospital/Institute of Mental Health, Beijing 100191, 
      China; Key Laboratory of Mental Health, Ministry of Health, Peking University, 
      Beijing 100191, China.
FAU - Qian, Qiujin
AU  - Qian Q
AD  - Peking University Sixth Hospital/Institute of Mental Health, Beijing 100191, 
      China; Key Laboratory of Mental Health, Ministry of Health, Peking University, 
      Beijing 100191, China. Electronic address: qianqiujin@bjmu.edu.cn.
FAU - Wang, Yufeng
AU  - Wang Y
AD  - Peking University Sixth Hospital/Institute of Mental Health, Beijing 100191, 
      China; Key Laboratory of Mental Health, Ministry of Health, Peking University, 
      Beijing 100191, China. Electronic address: wangyf@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140314
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Asian People/*genetics
MH  - Attention Deficit Disorder with Hyperactivity/*blood/*genetics
MH  - Brain-Derived Neurotrophic Factor/*blood/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - China/ethnology
MH  - Ethnicity/genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic/*genetics
MH  - *Sex Characteristics
MH  - Valine/genetics
OTO - NOTNLM
OT  - ADHD
OT  - Association
OT  - BDNF
OT  - Plasma
OT  - Polymorphism
OT  - Sex-specific
EDAT- 2014/04/10 06:00
MHDA- 2015/04/04 06:00
CRDT- 2014/04/10 06:00
PHST- 2013/10/30 00:00 [received]
PHST- 2014/02/13 00:00 [revised]
PHST- 2014/03/06 00:00 [accepted]
PHST- 2014/04/10 06:00 [entrez]
PHST- 2014/04/10 06:00 [pubmed]
PHST- 2015/04/04 06:00 [medline]
AID - S0165-1781(14)00213-3 [pii]
AID - 10.1016/j.psychres.2014.03.011 [doi]
PST - ppublish
SO  - Psychiatry Res. 2014 Jul 30;217(3):191-7. doi: 10.1016/j.psychres.2014.03.011. 
      Epub 2014 Mar 14.