PMID- 24713691
OWN - NLM
STAT- MEDLINE
DCOM- 20141229
LR  - 20211021
IS  - 1096-0929 (Electronic)
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 139
IP  - 2
DP  - 2014 Jun
TI  - Relative potency for altered humoral immunity induced by polybrominated and 
      polychlorinated dioxins/furans in female B6C3F1/N mice.
PG  - 488-500
LID - 10.1093/toxsci/kfu041 [doi]
AB  - The use of brominated flame retardants and incineration of bromine-containing 
      materials has lead to an increase in polybrominated dibenzo-p-dioxins and 
      dibenzofurans (PBDD/Fs) in the environment. Measurable amounts of PBDD/Fs have 
      been detected in soil, seafood, and human breast milk and serum. Studies indicate 
      that the relative potencies of some PBDD/Fs based on enzyme induction are 
      equivalent to those of some polychlorinated dibenzo-p-dioxins and dibenzofurans. 
      To assess the humoral immunity relative potencies of PBDD/Fs and compare them to 
      their chlorinated analogs, female B6C3F1/N mice received a single oral exposure 
      to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrabromodibenzofuran 
      (TBDF), 2,3,7,8-tetrachlorodibenzofuran (TCDF), 1,2,3,7,8-pentabromodibenzofuran 
      (1PeBDF), 1,2,3,7,8-pentachlorodibenzofuran (1PeCDF), 
      2,3,4,7,8-pentabromodibenzofuran (4PeBDF), 2,3,4,7,8-pentachlorodibenzofuran 
      (4PeCDF), 2,3-dibromo-7,8-dichlorodibenzo-p-dioxin (DBDCDD), or 
      2,3,7-tribromodibenzo-p-dioxin (TriBDD). Inhibition of the immunoglobulin M (IgM) 
      antibody forming cell response was measured 4 days following immunization with 
      sheep red blood cells. The data were fit to a Hill model to estimate the ED50 for 
      inhibition. Expression of xenobiotic metabolizing enzyme (XME) and thyroxine 
      transport protein (Ttr) genes in liver was measured by PCR to assess aryl 
      hydrocarbon-mediated responses. TCDD, TBDF, TCDF, 1PeBDF, 4PeBDF, 4PeCDF, and 
      DBDCDD suppressed the IgM antibody response and Ttr gene expression, and 
      upregulated phase I XME genes. 1PeCDF suppressed the IgM antibody response but 
      only upregulated phase I XME genes; TriBDD had no effect on antibody response. 
      The rank order of potency (ED50) for these chemicals was 
      TCDD>TBDF>4PeBDF>TCDF/4PeCDF/1PeBDF>1PeCDF. Whereas TCDD was the most potent 
      compound tested, the brominated analogs were more potent than their chlorinated 
      analogs, suggesting that these compounds should be considered in toxic 
      equivalency factor evaluation and risk assessment.
FAU - Frawley, Rachel
AU  - Frawley R
AD  - Division of the National Toxicology Program, National Institute of Environmental 
      Health Sciences.
FAU - DeVito, Michael
AU  - DeVito M
FAU - Walker, Nigel J
AU  - Walker NJ
FAU - Birnbaum, Linda
AU  - Birnbaum L
FAU - White, Kimber Jr
AU  - White K Jr
FAU - Smith, Matthew
AU  - Smith M
FAU - Maynor, Timothy
AU  - Maynor T
FAU - Recio, Leslie
AU  - Recio L
FAU - Germolec, Dori
AU  - Germolec D
LA  - eng
GR  - N01-ES-00005/ES/NIEHS NIH HHS/United States
GR  - N01-ES-55538/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140408
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Benzofurans)
RN  - 0 (Dioxins)
RN  - 0 (Hydrocarbons, Brominated)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Animals
MH  - Benzofurans/chemistry/*toxicity
MH  - Dioxins/chemistry/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Erythrocytes/immunology
MH  - Female
MH  - Gene Expression Profiling
MH  - Hydrocarbons, Brominated/chemistry/*toxicity
MH  - Hydrocarbons, Chlorinated/chemistry/*toxicity
MH  - Immunity, Humoral/*drug effects
MH  - Immunoglobulin M/immunology
MH  - Liver/drug effects/enzymology/metabolism
MH  - Mice, Inbred Strains
MH  - Molecular Structure
MH  - Spleen/drug effects/immunology
MH  - Transcriptome
PMC - PMC4031622
OTO - NOTNLM
OT  - 2
OT  - 3
OT  - 7
OT  - 8-tetrachlorodibenzo-p-dioxin
OT  - IgM antibody forming cell
OT  - TEF
OT  - brominated dioxins
OT  - brominated furans
OT  - chlorinated furans
OT  - relative potency
OT  - toxic equivalency factor
EDAT- 2014/04/10 06:00
MHDA- 2014/12/30 06:00
PMCR- 2015/06/01
CRDT- 2014/04/10 06:00
PHST- 2014/04/10 06:00 [entrez]
PHST- 2014/04/10 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - kfu041 [pii]
AID - 10.1093/toxsci/kfu041 [doi]
PST - ppublish
SO  - Toxicol Sci. 2014 Jun;139(2):488-500. doi: 10.1093/toxsci/kfu041. Epub 2014 Apr 
      8.