PMID- 24714139
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1108-7471 (Print)
IS  - 1792-7463 (Electronic)
IS  - 1108-7471 (Linking)
VI  - 25
IP  - 2
DP  - 2012
TI  - Effects of Helicobacter pylori infection and long-term proton pump inhibitor use 
      on enterochromaffin-like cells.
PG  - 123-127
AB  - BACKGROUND: Excessive release of gastrin leads to hypertrophy and hyperplasia of 
      enterochromaffin-like cells (ECL) and prolonged stimulation of these cells causes 
      functional impairment. The purpose of this study was to investigate the effect of 
      Helicobacter pylori (H. pylori) infection and long-term proton pump inhibitors 
      (PPI) use on ECL cells. METHODS: Fifteen patients who underwent endoscopy because 
      of dyspeptic symptoms were enrolled in the present study. Biopsies were taken 
      from corpus and antrum and existence of H. pylori was investigated with culture, 
      cytology and CLOtest. The patients were divided into 3 groups. Group-A: H. 
      pylori-negative, never treated previously with PPI; Group-B: H. pylori-positive, 
      never treated previously with PPI; and group-C: H. pylori-negative and 
      continuously treated with PPI for more than 6 months before the subject 
      recruitment period. The features of ECL cell in oxyntic glands were examined with 
      electron microscopy on biopsy specimens. RESULTS: ECL cells were completely 
      normal in Group A. In group B, moderate hyperplasia and vacuolization was seen in 
      ECL cells. In group C, ECL cell hyperplasia was observed and vacuoles with 
      greater amounts of granules in enlarged vesicles were found more intensely in 
      cytoplasm. CONCLUSION: The use of PPI for a long period of time and presence of 
      H. pylori infection are risk factors for ECL hyperplasia.
FAU - Bektas, Mehmet
AU  - Bektas M
AD  - Department of Gastroenterology (Mehmet Bektas, Hulya Cetinkaya, Murat Toruner, 
      Onur Keskin, Irfan Soykan, Esen Ismet Oktay, Esin Korkut, Yusuf Ustun, Kadir 
      Bahar).
FAU - Sarac, Nursen
AU  - Sarac N
AD  - Department of Histology and Embryology (Nursen Sarac, Esra Erdemli), Ankara 
      University School of Medicine.
FAU - Cetinkaya, Hulya
AU  - Cetinkaya H
AD  - Department of Gastroenterology (Mehmet Bektas, Hulya Cetinkaya, Murat Toruner, 
      Onur Keskin, Irfan Soykan, Esen Ismet Oktay, Esin Korkut, Yusuf Ustun, Kadir 
      Bahar).
FAU - Toruner, Murat
AU  - Toruner M
AD  - Department of Gastroenterology (Mehmet Bektas, Hulya Cetinkaya, Murat Toruner, 
      Onur Keskin, Irfan Soykan, Esen Ismet Oktay, Esin Korkut, Yusuf Ustun, Kadir 
      Bahar).
FAU - Erdemli, Esra
AU  - Erdemli E
AD  - Department of Histology and Embryology (Nursen Sarac, Esra Erdemli), Ankara 
      University School of Medicine.
FAU - Keskin, Onur
AU  - Keskin O
AD  - Department of Gastroenterology (Mehmet Bektas, Hulya Cetinkaya, Murat Toruner, 
      Onur Keskin, Irfan Soykan, Esen Ismet Oktay, Esin Korkut, Yusuf Ustun, Kadir 
      Bahar).
FAU - Soykan, Irfan
AU  - Soykan I
AD  - Department of Gastroenterology (Mehmet Bektas, Hulya Cetinkaya, Murat Toruner, 
      Onur Keskin, Irfan Soykan, Esen Ismet Oktay, Esin Korkut, Yusuf Ustun, Kadir 
      Bahar).
FAU - Oktay, Esen Ismet
AU  - Oktay EI
AD  - Department of Gastroenterology (Mehmet Bektas, Hulya Cetinkaya, Murat Toruner, 
      Onur Keskin, Irfan Soykan, Esen Ismet Oktay, Esin Korkut, Yusuf Ustun, Kadir 
      Bahar).
FAU - Korkut, Esin
AU  - Korkut E
AD  - Department of Gastroenterology (Mehmet Bektas, Hulya Cetinkaya, Murat Toruner, 
      Onur Keskin, Irfan Soykan, Esen Ismet Oktay, Esin Korkut, Yusuf Ustun, Kadir 
      Bahar).
FAU - Ustun, Yusuf
AU  - Ustun Y
AD  - Department of Gastroenterology (Mehmet Bektas, Hulya Cetinkaya, Murat Toruner, 
      Onur Keskin, Irfan Soykan, Esen Ismet Oktay, Esin Korkut, Yusuf Ustun, Kadir 
      Bahar).
FAU - Bahar, Kadir
AU  - Bahar K
AD  - Department of Gastroenterology (Mehmet Bektas, Hulya Cetinkaya, Murat Toruner, 
      Onur Keskin, Irfan Soykan, Esen Ismet Oktay, Esin Korkut, Yusuf Ustun, Kadir 
      Bahar).
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Ann Gastroenterol
JT  - Annals of gastroenterology
JID - 101121847
PMC - PMC3959398
OTO - NOTNLM
OT  - Enterochromaffin-like cells
OT  - Helicobacter pylori infection
OT  - proton pump inhibitors
COIS- Conflict of Interest: None
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
PMCR- 2012/01/01
CRDT- 2014/04/10 06:00
PHST- 2011/11/07 00:00 [received]
PHST- 2012/02/13 00:00 [accepted]
PHST- 2014/04/10 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - AnnGastroenterol-25-123 [pii]
PST - ppublish
SO  - Ann Gastroenterol. 2012;25(2):123-127.