PMID- 24715233
OWN - NLM
STAT- MEDLINE
DCOM- 20150102
LR  - 20211021
IS  - 1877-8755 (Electronic)
IS  - 1138-7548 (Linking)
VI  - 70
IP  - 2
DP  - 2014 Jun
TI  - Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and 
      its metabolite 3, 3'- diindolylmethane in C57BL/6J mice.
PG  - 525-34
LID - 10.1007/s13105-014-0332-5 [doi]
AB  - In this study, we have investigated the effect of the nutritive phytochemicals, 
      indole-3-carbinol (I3C) and its metabolite, 3, 3'- diindolylmethane (DIM) on 
      oxidative stress developed in type 2 diabetes mellitus (T2DM). This work was 
      carried out in the genetically modified mouse (C57BL/6J mice) that closely 
      simulated the metabolic abnormalities of the human disease after the 
      administration of high fat diet (HFD). Glucose, insulin, hemoglobin (Hb), 
      glycated hemoglobin (HbA1c), thiobarbituric acid reactive substances (TBARS), 
      lipid hydroperoxides (LOOH), conjugated dienes (CD), superoxide dismutase (SOD), 
      catalase (CAT), glutathione peroxidase (GPx), vitamin C, vitamin E, and reduced 
      glutathione (GSH) levels were monitored in all the groups. Treatments positively 
      modulate the glucose, insulin, and Hb and HbA1c levels in HFD mice. TBARS, LOOH, 
      and CD were decreased in treatment groups when compared to the HFD group. 
      Treatments increase SOD, CAT, GPx levels (erythrocyte, liver, kidney, and heart) 
      and vitamin C, vitamin E, and GSH levels (plasma, liver, kidney, and heart) in 
      diabetic mice. From the study, it was clear that the antioxidant-scavenging 
      action were accelerated in mice treated with DIM than the I3C treatment group 
      which was comparable with the standard drug metformin.
FAU - Jayakumar, Poornima
AU  - Jayakumar P
AD  - Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai 
      University, Annamalainagar, 608002, Tamilnadu, India.
FAU - Pugalendi, Kodukkur Vishwanath
AU  - Pugalendi KV
FAU - Sankaran, Mirunalini
AU  - Sankaran M
LA  - eng
PT  - Journal Article
DEP - 20140409
PL  - Spain
TA  - J Physiol Biochem
JT  - Journal of physiology and biochemistry
JID - 9812509
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Hemoglobins)
RN  - 0 (Indoles)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - C11E72455F (indole-3-carbinol)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - SSZ9HQT61Z (3,3'-diindolylmethane)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Blood Glucose/metabolism
MH  - Catalase/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Hemoglobins/metabolism
MH  - Hyperglycemia/*complications
MH  - Indoles/*pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Oxidative Stress/*drug effects
MH  - Superoxide Dismutase/metabolism
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2014/04/10 06:00
MHDA- 2015/01/03 06:00
CRDT- 2014/04/10 06:00
PHST- 2013/05/27 00:00 [received]
PHST- 2014/03/12 00:00 [accepted]
PHST- 2014/04/10 06:00 [entrez]
PHST- 2014/04/10 06:00 [pubmed]
PHST- 2015/01/03 06:00 [medline]
AID - 10.1007/s13105-014-0332-5 [doi]
PST - ppublish
SO  - J Physiol Biochem. 2014 Jun;70(2):525-34. doi: 10.1007/s13105-014-0332-5. Epub 
      2014 Apr 9.