PMID- 24717328
OWN - NLM
STAT- MEDLINE
DCOM- 20141216
LR  - 20211021
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 268
DP  - 2014 Jul 15
TI  - Antidepressant effects of resveratrol in an animal model of depression.
PG  - 1-7
LID - S0166-4328(14)00218-6 [pii]
LID - 10.1016/j.bbr.2014.03.052 [doi]
AB  - Resveratrol (3,4',5-trihydroxy-trans-stilbene) is a natural non-flavonoid 
      polyphenol antioxidant extracted from red grapes in the processing of wine. 
      Initially it was studied for its potential as anticancer drug, and later was 
      found to reduce cardiovascular disease. More recently resveratrol was shown to 
      alleviate depressive-like symptoms induced by stress or other means in mice and 
      rats. The major purpose of this study was to investigate whether resveratrol 
      would manifest an antidepressant effect in Wistar-Kyoto (WKY) rats, a putative 
      and non-induced animal model of depression, and whether this effect might be 
      associated with an increase in hippocampal and frontal cortical brain-derived 
      neurotrophic factor (BDNF), a protein implicated in chronic effects of many 
      antidepressants. Adult male WKY rats were injected with two doses of resveratrol 
      (10 and 40 mg/kg, i.p.) and their behavior in the open field locomotor activity 
      (LMA), forced swim test (FST: a measure of helplessness), and sucrose preference 
      test (SPT: a measure of anhedonia) was evaluated after a single acute injection 
      or following 7 days of daily treatment. Both acute and chronic administration of 
      resveratrol resulted in a dose-dependent decrease in FST. However, only chronic 
      resveratrol resulted in dose-dependent increase in sucrose consumption. LMA was 
      not affected by any treatment. Parallel to the observed behavioral effects the 
      level of hippocampal, but not frontal cortical, BDNF was also dose-dependently 
      elevated after chronic resveratrol administration. These findings indicate an 
      antidepressant-like effect of resveratrol in an animal model of depression 
      possibly via activation of hippocampal BDNF, and suggest therapeutic potential of 
      resveratrol in at least a subpopulation of depressed patients.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Hurley, Laura L
AU  - Hurley LL
AD  - Department of Pharmacology, Howard University College of Medicine, Washington, DC 
      20059, USA.
FAU - Akinfiresoye, Luli
AU  - Akinfiresoye L
AD  - Department of Pharmacology, Howard University College of Medicine, Washington, DC 
      20059, USA.
FAU - Kalejaiye, Olubukola
AU  - Kalejaiye O
AD  - Department of Pharmacology, Howard University College of Medicine, Washington, DC 
      20059, USA.
FAU - Tizabi, Yousef
AU  - Tizabi Y
AD  - Department of Pharmacology, Howard University College of Medicine, Washington, DC 
      20059, USA. Electronic address: ytizabi@howard.edu.
LA  - eng
GR  - G12 MD007597/MD/NIMHD NIH HHS/United States
GR  - S06 GM008016/GM/NIGMS NIH HHS/United States
GR  - 2 SO6 GM08016-39/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140406
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Stilbenes)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Anhedonia/drug effects
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depressive Disorder/*drug therapy/metabolism
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Frontal Lobe/*drug effects/metabolism
MH  - Hippocampus/*drug effects/metabolism
MH  - Male
MH  - Motor Activity/drug effects
MH  - Neuropsychological Tests
MH  - Rats, Inbred WKY
MH  - Resveratrol
MH  - Stilbenes/*pharmacology
MH  - Time Factors
PMC - PMC4033784
MID - NIHMS584372
OTO - NOTNLM
OT  - Animal model
OT  - BDNF
OT  - Depression
OT  - Hippocampus
OT  - Resveratrol
EDAT- 2014/04/11 06:00
MHDA- 2014/12/17 06:00
PMCR- 2015/07/15
CRDT- 2014/04/11 06:00
PHST- 2014/02/04 00:00 [received]
PHST- 2014/03/25 00:00 [revised]
PHST- 2014/03/29 00:00 [accepted]
PHST- 2014/04/11 06:00 [entrez]
PHST- 2014/04/11 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
PHST- 2015/07/15 00:00 [pmc-release]
AID - S0166-4328(14)00218-6 [pii]
AID - 10.1016/j.bbr.2014.03.052 [doi]
PST - ppublish
SO  - Behav Brain Res. 2014 Jul 15;268:1-7. doi: 10.1016/j.bbr.2014.03.052. Epub 2014 
      Apr 6.