PMID- 24717346
OWN - NLM
STAT- MEDLINE
DCOM- 20150223
LR  - 20140702
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Linking)
VI  - 112
IP  - 1
DP  - 2014 Jul 1
TI  - Primary motor cortex disinhibition during motor skill learning.
PG  - 156-64
LID - 10.1152/jn.00893.2013 [doi]
AB  - Motor learning requires practice over a period of time and depends on brain 
      plasticity, yet even for relatively simple movements, there are multiple practice 
      strategies that can be used for skill acquisition. We investigated the role of 
      intracortical inhibition in the primary motor cortex (M1) during motor skill 
      learning. Event-related transcranial magnetic stimulation (TMS) was used to 
      assess corticomotor excitability and inhibition thought to involve synaptic and 
      extrasynaptic gamma-aminobutyric acid (GABA). Short intracortical inhibition (SICI) 
      was assessed using 1- and 2.5-ms interstimulus intervals (ISIs). Participants 
      learned a novel, sequential pinch-grip task on a computer in either a repetitive 
      or interleaved practice structure. Both practice structures showed equivalent 
      levels of motor performance at the end of acquisition and at retention 1 wk 
      later. There was a novel task-related modulation of 1-ms SICI. Repetitive 
      practice elicited a greater reduction of 1- and 2.5-ms SICI, i.e., disinhibition, 
      between rest and task acquisition, compared with interleaved practice. These 
      novel findings support the use of a repetitive practice structure for motor 
      learning because the associated effects within M1 have relevance for motor 
      rehabilitation.
CI  - Copyright (c) 2014 the American Physiological Society.
FAU - Coxon, James P
AU  - Coxon JP
AD  - Movement Neuroscience Laboratory, Department of Sport & Exercise Science, The 
      University of Auckland, Auckland, New Zealand; and Centre for Brain Research, The 
      University of Auckland, Auckland, New Zealand.
FAU - Peat, Nicola M
AU  - Peat NM
AD  - Movement Neuroscience Laboratory, Department of Sport & Exercise Science, The 
      University of Auckland, Auckland, New Zealand; and.
FAU - Byblow, Winston D
AU  - Byblow WD
AD  - Movement Neuroscience Laboratory, Department of Sport & Exercise Science, The 
      University of Auckland, Auckland, New Zealand; and Centre for Brain Research, The 
      University of Auckland, Auckland, New Zealand w.byblow@auckland.ac.nz.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140409
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Adult
MH  - Evoked Potentials, Motor
MH  - Female
MH  - Humans
MH  - *Learning
MH  - Male
MH  - Motor Cortex/*physiology
MH  - *Motor Skills
MH  - *Neural Inhibition
MH  - Transcranial Magnetic Stimulation
OTO - NOTNLM
OT  - GABA
OT  - intracortical inhibition
OT  - motor skill learning
OT  - repetitive practice
OT  - transcranial magnetic stimulation
EDAT- 2014/04/11 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/04/11 06:00
PHST- 2014/04/11 06:00 [entrez]
PHST- 2014/04/11 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - jn.00893.2013 [pii]
AID - 10.1152/jn.00893.2013 [doi]
PST - ppublish
SO  - J Neurophysiol. 2014 Jul 1;112(1):156-64. doi: 10.1152/jn.00893.2013. Epub 2014 
      Apr 9.