PMID- 24718028
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20211021
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Linking)
VI  - 15
IP  - 4
DP  - 2014 Apr
TI  - Association of the HLA-B*52 allele with non-progression to AIDS in Brazilian 
      HIV-1-infected individuals.
PG  - 256-62
LID - 10.1038/gene.2014.14 [doi]
AB  - Several human leukocyte antigen (HLA) class I alleles are associated with the 
      susceptibility to human immunodeficiency virus-1 (HIV-1) infection and/or AIDS 
      progression. Of these, the HLA-B alleles are considered the strongest genetic 
      determinant of disease outcome. We evaluated the influence of the HLA-B alleles 
      on AIDS progression among HIV-1-positive individuals from Rio de Janeiro, Brazil, 
      who were categorized as rapid progressors (RPs), typical progressors (TPs) or 
      long-term non-progressors (LTNPs). In this study, significant differences in 
      HLA-B allele frequencies were observed among the three progression groups for the 
      B*48, B*49 and B*52 alleles. After controlling for other factors associated with 
      AIDS progression, the presence of the B*52 allele was shown to be a significant 
      protective factor (hazard ratio (HR) 0.49 (95% confidence interval (CI) 
      0.27-0.90) P<0.03). Although no direct association was observed between the 
      presence of the B*27 or B*57 allele and the LTNP profile compared with the TP or 
      RP groups, the adjusted model confirmed that these alleles are protective factors 
      against AIDS progression (HR 0.62 (95% CI 0.38-0.99) P<0.05), as previously 
      described. These data corroborate the existence of significant differences in 
      HLA-B allele frequencies among the distinct AIDS progression profiles and further 
      elucidate the role of HLA alleles in the outcome of HIV infections in diverse 
      populations.
FAU - Teixeira, S L M
AU  - Teixeira SL
AD  - Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio 
      de Janeiro, Brazil.
FAU - de Sa, N B R
AU  - de Sa NB
AD  - Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio 
      de Janeiro, Brazil.
FAU - Campos, D P
AU  - Campos DP
AD  - Evandro Chagas Clinical Research Institute, FIOCRUZ, Rio de Janeiro, Brazil.
FAU - Coelho, A B
AU  - Coelho AB
AD  - Evandro Chagas Clinical Research Institute, FIOCRUZ, Rio de Janeiro, Brazil.
FAU - Guimaraes, M L
AU  - Guimaraes ML
AD  - Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio 
      de Janeiro, Brazil.
FAU - Leite, T C N F
AU  - Leite TC
AD  - Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio 
      de Janeiro, Brazil.
FAU - Veloso, V G
AU  - Veloso VG
AD  - Evandro Chagas Clinical Research Institute, FIOCRUZ, Rio de Janeiro, Brazil.
FAU - Morgado, M G
AU  - Morgado MG
AD  - Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio 
      de Janeiro, Brazil.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140410
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA-B52 Antigen)
SB  - IM
MH  - *Acquired Immunodeficiency Syndrome/genetics/immunology
MH  - Adolescent
MH  - Adult
MH  - *Alleles
MH  - Brazil
MH  - Female
MH  - Gene Frequency/*immunology
MH  - HIV-1/*immunology
MH  - *HLA-B52 Antigen/genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2014/04/11 06:00
MHDA- 2015/02/13 06:00
CRDT- 2014/04/11 06:00
PHST- 2013/11/08 00:00 [received]
PHST- 2014/02/26 00:00 [revised]
PHST- 2014/02/28 00:00 [accepted]
PHST- 2014/04/11 06:00 [entrez]
PHST- 2014/04/11 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
AID - gene201414 [pii]
AID - 10.1038/gene.2014.14 [doi]
PST - ppublish
SO  - Genes Immun. 2014 Apr;15(4):256-62. doi: 10.1038/gene.2014.14. Epub 2014 Apr 10.