PMID- 24718282
OWN - NLM
STAT- MEDLINE
DCOM- 20150819
LR  - 20220317
IS  - 1538-7755 (Electronic)
IS  - 1055-9965 (Print)
IS  - 1055-9965 (Linking)
VI  - 23
IP  - 7
DP  - 2014 Jul
TI  - Serum immunoglobulin e and risk of pancreatic cancer in the prostate, lung, 
      colorectal, and ovarian cancer screening trial.
PG  - 1414-20
LID - 10.1158/1055-9965.EPI-13-1359 [doi]
AB  - Epidemiologic studies have consistently found that self-reported allergies are 
      associated with reduced risk of pancreatic cancer. Our aim was to prospectively 
      assess the relationship between serum immunoglobulin E (IgE), a marker of 
      allergy, and risk. This nested case-control study within the Prostate, Lung, 
      Colorectal, and Ovarian Cancer Screening Trial (PLCO) included subjects enrolled 
      in 1994 to 2001 and followed through 2010. There were 283 cases of pancreatic 
      cancer and 544 controls matched on age, gender, race, and calendar date of blood 
      draw. Using the ImmunoCAP system, we measured total IgE (normal, borderline, 
      elevated), IgE to respiratory allergens, and IgE to food allergens (negative or 
      positive) in serum collected at baseline. Odds ratios (OR) and 95% confidence 
      intervals (CI) were estimated using conditional logistic regression. We assessed 
      interactions with age, gender, smoking, body mass index, and time between 
      randomization and case diagnosis. Overall, there was no association between the 
      IgE measures and risk. We found a statistically significant interaction by 
      baseline age: in those aged >/=65 years, elevated risks were observed for 
      borderline total IgE (OR, 1.43; 95% CI, 0.88-2.32) and elevated total IgE (OR, 
      1.98; 95% CI, 1.16-3.37) and positive IgE to food allergens (OR, 2.83; 95% CI, 
      1.29-6.20); among participants <65 years, ORs were <1. Other interactions were 
      not statistically significant. The reduced risk of pancreatic cancer associated 
      with self-reported allergies is not reflected in serum IgE.
CI  - (c)2014 American Association for Cancer Research.
FAU - Olson, Sara H
AU  - Olson SH
AD  - Authors' Affiliations: Department of Epidemiology and Biostatistics; 
      olsons@mskcc.org.
FAU - Hsu, Meier
AU  - Hsu M
AD  - Authors' Affiliations: Department of Epidemiology and Biostatistics;
FAU - Wiemels, Joseph L
AU  - Wiemels JL
AD  - Department of Epidemiology and Biostatistics, School of Medicine, University of 
      California, San Francisco, San Francisco, California;
FAU - Bracci, Paige M
AU  - Bracci PM
AD  - Department of Epidemiology and Biostatistics, School of Medicine, University of 
      California, San Francisco, San Francisco, California;
FAU - Zhou, Mi
AU  - Zhou M
AD  - Department of Epidemiology and Biostatistics, School of Medicine, University of 
      California, San Francisco, San Francisco, California;
FAU - Patoka, Joseph
AU  - Patoka J
AD  - Department of Epidemiology and Biostatistics, School of Medicine, University of 
      California, San Francisco, San Francisco, California;
FAU - Reisacher, William R
AU  - Reisacher WR
AD  - Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical 
      College, New York, New York;
FAU - Wang, Julie
AU  - Wang J
AD  - Division of Pediatric Allergy and Immunology, Mt. Sinai Medical Center;
FAU - Kurtz, Robert C
AU  - Kurtz RC
AD  - Department of Medicine, Memorial Sloan Kettering Cancer Center;
FAU - Silverman, Debra T
AU  - Silverman DT
AD  - Occupational and Environmental Epidemiology Branch; and.
FAU - Stolzenberg-Solomon, Rachael Z
AU  - Stolzenberg-Solomon RZ
AD  - Branch of Nutritional Epidemiology, Division of Cancer Epidemiology and Genetics, 
      National Cancer Institute, Rockville, Maryland.
LA  - eng
GR  - P30 CA008748/CA/NCI NIH HHS/United States
GR  - U01 CA150138/CA/NCI NIH HHS/United States
GR  - U01CA150138/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20140409
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American 
      Association for Cancer Research, cosponsored by the American Society of 
      Preventive Oncology
JID - 9200608
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adenocarcinoma/*blood/*epidemiology
MH  - Aged
MH  - Case-Control Studies
MH  - Early Detection of Cancer
MH  - Female
MH  - Humans
MH  - Hypersensitivity/epidemiology
MH  - Immunoglobulin E/*blood
MH  - Incidence
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Odds Ratio
MH  - Pancreatic Neoplasms/*blood/*epidemiology
MH  - Risk Factors
PMC - PMC4120187
MID - NIHMS585078
EDAT- 2014/04/11 06:00
MHDA- 2015/08/20 06:00
PMCR- 2015/07/01
CRDT- 2014/04/11 06:00
PHST- 2014/04/11 06:00 [entrez]
PHST- 2014/04/11 06:00 [pubmed]
PHST- 2015/08/20 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - 1055-9965.EPI-13-1359 [pii]
AID - 10.1158/1055-9965.EPI-13-1359 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2014 Jul;23(7):1414-20. doi: 
      10.1158/1055-9965.EPI-13-1359. Epub 2014 Apr 9.