PMID- 24719076
OWN - NLM
STAT- MEDLINE
DCOM- 20141218
LR  - 20161125
IS  - 1545-9616 (Print)
IS  - 1545-9616 (Linking)
VI  - 13
IP  - 4 Suppl
DP  - 2014 Apr
TI  - Understanding, avoiding, and treating potential adverse events following the use 
      of injectable poly-L-lactic acid for facial and nonfacial volumization.
PG  - s35-9
AB  - Injection-related adverse events (AEs) may occur with the use of any injectable 
      substance, including all commercially available fillers. The most common of these 
      AEs include discomfort, bruising, edema, and erythema, which are generally 
      transient and resolve spontaneously. The majority of AEs widely felt to be 
      associated with poly-L-lactic acid (PLLA) are papules, nodules, and granulomas. 
      Papules and nodules, which are histologically distinct from granulomas, tend to 
      arise several weeks after injection, are generally palpable, asymptomatic, and 
      nonvisible, and will typically resolve on their own, but can be camouflaged with 
      the use of hyaluronic acid. They generally result from suboptimal product 
      reconstitution or placement and, as such, their incidence can be minimized by 
      improved injection methodology. In contrast, true inflammatory granulomas are 
      very rare (incidence 0.01%-0.1%), seem to be systemic in nature, and represent an 
      overabundance of host reaction to PLLA. Granulomas may become apparent months or 
      years post-injection and may persist and grow over time. Their treatment is 
      geared toward halting the increased secretion of interstitial substances and 
      invasion of cells, and may include the administration of steroids and 
      antimetabolites such as 5-fluorouracil.
FAU - Vleggaar, Danny
AU  - Vleggaar D
FAU - Fitzgerald, Rebecca
AU  - Fitzgerald R
FAU - Lorenc, Z Paul
AU  - Lorenc ZP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Drugs Dermatol
JT  - Journal of drugs in dermatology : JDD
JID - 101160020
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 459TN2L5F5 (poly(lactide))
SB  - IM
MH  - Cosmetic Techniques/*adverse effects
MH  - Face
MH  - Granuloma/etiology/therapy
MH  - Humans
MH  - Injections
MH  - Lactic Acid/administration & dosage/*adverse effects
MH  - Polyesters
MH  - Polymers/administration & dosage/*adverse effects
MH  - Skin Aging/*drug effects
EDAT- 2014/04/11 06:00
MHDA- 2014/12/19 06:00
CRDT- 2014/04/11 06:00
PHST- 2014/04/11 06:00 [entrez]
PHST- 2014/04/11 06:00 [pubmed]
PHST- 2014/12/19 06:00 [medline]
AID - S1545961614S0035X [pii]
PST - ppublish
SO  - J Drugs Dermatol. 2014 Apr;13(4 Suppl):s35-9.