PMID- 24719092
OWN - NLM
STAT- MEDLINE
DCOM- 20140616
LR  - 20211021
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 34
IP  - 15
DP  - 2014 Apr 9
TI  - A family of nonclassical class I MHC genes contributes to ultrasensitive 
      chemodetection by mouse vomeronasal sensory neurons.
PG  - 5121-33
LID - 10.1523/JNEUROSCI.0186-14.2014 [doi]
AB  - The mouse vomeronasal organ (VNO) has a pivotal role in chemical communication. 
      The vomeronasal sensory neuroepithelium consists of distinct populations of 
      vomeronasal sensory neurons (VSNs). A subset of VSNs, with cell bodies in the 
      basal part of the basal layer, coexpress Vmn2r G-protein-coupled receptor genes 
      with H2-Mv genes, a family of nine nonclassical class I major histocompatibility 
      complex genes. The in vivo, physiological roles of the H2-Mv gene family remain 
      mysterious more than a decade after the discovery of combinatorial H2-Mv gene 
      expression in VSNs. Here, we have taken a genetic approach and have deleted the 
      530 kb cluster of H2-Mv genes in the mouse germline by chromosome engineering. 
      Homozygous mutant mice (DeltaH2Mv mice) are viable and fertile. There are no major 
      anatomical defects in their VNO and accessory olfactory bulb (AOB). Their VSNs 
      can be stimulated with chemostimuli (peptides and proteins) to the same maximum 
      responses as VSNs of wild-type mice, but require much higher concentrations. This 
      physiological phenotype is displayed at the single-cell level and is cell 
      autonomous: single V2rf2-expressing VSNs, which normally coexpress H2-Mv genes, 
      display a decreased sensitivity to a peptide ligand in DeltaH2Mv mice, whereas single 
      V2r1b-expressing VSNs, which do not coexpress H2-Mv genes, show normal 
      sensitivity to a peptide ligand in DeltaH2Mv mice. Consistent with the greatly 
      decreased VSN sensitivity, DeltaH2Mv mice display pronounced deficits in aggressive 
      and sexual behaviors. Thus, H2-Mv genes are not absolutely essential for the 
      generation of physiological responses, but are required for ultrasensitive 
      chemodetection by a subset of VSNs.
FAU - Leinders-Zufall, Trese
AU  - Leinders-Zufall T
AD  - Department of Physiology, University of Saarland School of Medicine, 66421 
      Homburg, Germany, Max Planck Research Unit for Neurogenetics, 60438 Frankfurt, 
      Germany, and Department of Cell Biology and Center for Brain Integration 
      Research, Tokyo Medical and Dental University, Graduate School of Medical and 
      Dental Science, Bunkyo-ku, Tokyo 113-8510, Japan.
FAU - Ishii, Tomohiro
AU  - Ishii T
FAU - Chamero, Pablo
AU  - Chamero P
FAU - Hendrix, Philipp
AU  - Hendrix P
FAU - Oboti, Livio
AU  - Oboti L
FAU - Schmid, Andreas
AU  - Schmid A
FAU - Kircher, Sarah
AU  - Kircher S
FAU - Pyrski, Martina
AU  - Pyrski M
FAU - Akiyoshi, Sachiko
AU  - Akiyoshi S
FAU - Khan, Mona
AU  - Khan M
FAU - Vaes, Evelien
AU  - Vaes E
FAU - Zufall, Frank
AU  - Zufall F
FAU - Mombaerts, Peter
AU  - Mombaerts P
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/metabolism
MH  - Cell Line
MH  - Chemoreceptor Cells/*metabolism/physiology
MH  - Female
MH  - Gene Deletion
MH  - Genes, MHC Class I/*genetics
MH  - Germ-Line Mutation
MH  - Homozygote
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Phenotype
MH  - Receptors, G-Protein-Coupled/genetics/metabolism
MH  - Sensory Thresholds
MH  - Sexual Behavior, Animal
MH  - Smell/*genetics
MH  - Vomeronasal Organ/cytology/*metabolism/physiology
PMC - PMC4050176
OTO - NOTNLM
OT  - accessory olfactory system
OT  - chemodetection
OT  - chromosome engineering
OT  - major histocompatibility complex
OT  - pheromone
OT  - vomeronasal receptor
EDAT- 2014/04/11 06:00
MHDA- 2014/06/17 06:00
PMCR- 2014/10/09
CRDT- 2014/04/11 06:00
PHST- 2014/04/11 06:00 [entrez]
PHST- 2014/04/11 06:00 [pubmed]
PHST- 2014/06/17 06:00 [medline]
PHST- 2014/10/09 00:00 [pmc-release]
AID - 34/15/5121 [pii]
AID - 0186-14 [pii]
AID - 10.1523/JNEUROSCI.0186-14.2014 [doi]
PST - ppublish
SO  - J Neurosci. 2014 Apr 9;34(15):5121-33. doi: 10.1523/JNEUROSCI.0186-14.2014.