PMID- 24719720
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140410
LR  - 20211021
IS  - 2074-1804 (Print)
IS  - 2074-1812 (Electronic)
IS  - 2074-1804 (Linking)
VI  - 16
IP  - 1
DP  - 2014 Jan
TI  - Effect of Early Treatment With Tirofiban on Initial TIMI Grade 3 Flow of Patients 
      With ST Elevation Myocardial Infarction.
PG  - e9641
LID - 10.5812/ircmj.9641 [doi]
LID - e9641
AB  - BACKGROUND: Before primary percutaneous coronary intervention (PCI) in patients 
      with ST elevation myocardial infarction (STEMI), it is not clear whether a 
      routine early administration of glycoprotein IIb/IIIa inhibitors in the emergency 
      ward is beneficial or their administration in selected cases in the 
      catheterization laboratory. OBJECTIVES: The present randomized clinical trial 
      sought to investigate whether an earlier administration of Tirofiban could exert 
      any impact on TIMI grade 3 flows and ST resolution in the electrocardiography of 
      patients with STEMI before primary PCI. MATERIALS AND METHODS: Patients with 
      STEMI within twelve hours of symptom commencement were included if primary PCI 
      was planned to be performed within ninety minutes of admission and excluded if 
      they had contraindications for Tirofiban. Seventy patients were randomized to 
      receive 25 mug/kg of bolus Tirofiban early in the emergency ward (the early 
      Tirofiban group) in three minutes and 70 did not receive Tirofiban (the control 
      group). The primary endpoint of the study was a Thrombolysis in Myocardial 
      Infarction (TIMI) grade 3 flows on the initial angiogram. The study is registered 
      as IRCT201105126463N1 in: www.irct.ir. RESULTS: The study population had a mean 
      age of 57.17 +/- 10.09 years and included 79.3 % males. TIMI grade 3 flow was seen 
      in 15 (21.4 %) patients of the Tirofiban group and 7 (10 %) of the control group 
      (P = 0.06, odds ratio = 0.407, and 95 % confidence interval = 0.155-1.072). 
      Complete ST resolution was seen in 30 (42.9 %) patients of the Tirofiban group 
      and 34 (48.6 %) of the control group (P = 0.5). CONCLUSION: Although TIMI grade 3 
      flows trended to be higher in the patients who received early Tirofiban in the 
      emergency ward, the difference did not constitute statistical significance and 
      possible benefits, therefore, require further clarification.
FAU - Salarifar, Mojtaba
AU  - Salarifar M
AD  - Department of Cardiology, Tehran University of Medical Sciences, Tehran Heart 
      Center Hospital, Tehran, IR Iran.
FAU - Mousavi, Mehdi
AU  - Mousavi M
AD  - Department of Cardiology, Alborz University of Medical Sciences, Shahid Rajai 
      Hospital, Karaj, IR Iran.
FAU - Yousefpour, Narges
AU  - Yousefpour N
AD  - Department of Cardiology, Tehran University of Medical Sciences, Tehran Heart 
      Center Hospital, Tehran, IR Iran.
FAU - Nematipour, Ebrahim
AU  - Nematipour E
AD  - Department of Cardiology, Tehran University of Medical Sciences, Tehran Heart 
      Center Hospital, Tehran, IR Iran.
FAU - Kassaian, Seyed Ebrahim
AU  - Kassaian SE
AD  - Department of Cardiology, Tehran University of Medical Sciences, Tehran Heart 
      Center Hospital, Tehran, IR Iran.
FAU - Poorhosseini, Hamidreza
AU  - Poorhosseini H
AD  - Department of Cardiology, Tehran University of Medical Sciences, Tehran Heart 
      Center Hospital, Tehran, IR Iran.
FAU - Hajizeinali, Alimohammad
AU  - Hajizeinali A
AD  - Department of Cardiology, Tehran University of Medical Sciences, Tehran Heart 
      Center Hospital, Tehran, IR Iran.
FAU - Alidoosti, Mohammad
AU  - Alidoosti M
AD  - Department of Cardiology, Tehran University of Medical Sciences, Tehran Heart 
      Center Hospital, Tehran, IR Iran.
FAU - Aghajani, Hassan
AU  - Aghajani H
AD  - Department of Cardiology, Tehran University of Medical Sciences, Tehran Heart 
      Center Hospital, Tehran, IR Iran.
FAU - Nozari, Younes
AU  - Nozari Y
AD  - Department of Cardiology, Tehran University of Medical Sciences, Tehran Heart 
      Center Hospital, Tehran, IR Iran.
FAU - Amirzadegan, Alireza
AU  - Amirzadegan A
AD  - Department of Cardiology, Tehran University of Medical Sciences, Tehran Heart 
      Center Hospital, Tehran, IR Iran.
FAU - Bozorgi, Ali
AU  - Bozorgi A
AD  - Department of Cardiology, Tehran University of Medical Sciences, Tehran Heart 
      Center Hospital, Tehran, IR Iran.
FAU - Genab, Yaser
AU  - Genab Y
AD  - Department of Cardiology, Tehran University of Medical Sciences, Tehran Heart 
      Center Hospital, Tehran, IR Iran.
LA  - eng
PT  - Journal Article
DEP - 20140105
PL  - Estonia
TA  - Iran Red Crescent Med J
JT  - Iranian Red Crescent medical journal
JID - 101319850
PMC - PMC3964438
OTO - NOTNLM
OT  - Angiography
OT  - Myocardial Infarction
OT  - Percutaneous Coronary Intervention
OT  - Tirofiban
EDAT- 2014/04/11 06:00
MHDA- 2014/04/11 06:01
PMCR- 2014/01/01
CRDT- 2014/04/11 06:00
PHST- 2012/12/16 00:00 [received]
PHST- 2013/08/12 00:00 [revised]
PHST- 2013/11/24 00:00 [accepted]
PHST- 2014/04/11 06:00 [entrez]
PHST- 2014/04/11 06:00 [pubmed]
PHST- 2014/04/11 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.5812/ircmj.9641 [doi]
PST - ppublish
SO  - Iran Red Crescent Med J. 2014 Jan;16(1):e9641. doi: 10.5812/ircmj.9641. Epub 2014 
      Jan 5.