PMID- 24719781
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140508
LR  - 20240321
IS  - 2162-3945 (Print)
IS  - 2162-397X (Electronic)
IS  - 2162-3945 (Linking)
VI  - 3
IP  - 2
DP  - 2014 Apr 1
TI  - Adipokines and insulin action: A sensitive issue.
PG  - 88-96
LID - 10.4161/adip.27552 [doi]
AB  - Obesity is a major public health concern and a strong risk factor for insulin 
      resistance, type 2 diabetes mellitus (T2DM), and cardiovascular disease. The last 
      two decades have seen a reconsideration of the role of white adipose tissue (WAT) 
      in whole body metabolism and insulin action. Adipose tissue-derived cytokines and 
      hormones, or adipokines, are likely mediators of metabolic function and 
      dysfunction. While several adipokines have been associated with obese and 
      insulin-resistant phenotypes, a select group has been linked with insulin 
      sensitivity, namely leptin, adiponectin, and more recently, adipolin. What is 
      known about these insulin-sensitizing molecules and their effects in healthy and 
      insulin resistant states is the subject of this review. There remains a 
      significant amount of research to do to fully elucidate the mechanisms of action 
      of these adipokines for development of therapeutics in metabolic disease.
FAU - Knights, Alexander J
AU  - Knights AJ
AD  - School of Biotechnology and Biomolecular Sciences; University of New South Wales; 
      Sydney, NSW Australia.
FAU - Funnell, Alister Pw
AU  - Funnell AP
AD  - School of Biotechnology and Biomolecular Sciences; University of New South Wales; 
      Sydney, NSW Australia.
FAU - Pearson, Richard Cm
AU  - Pearson RC
AD  - School of Biotechnology and Biomolecular Sciences; University of New South Wales; 
      Sydney, NSW Australia.
FAU - Crossley, Merlin
AU  - Crossley M
AD  - School of Biotechnology and Biomolecular Sciences; University of New South Wales; 
      Sydney, NSW Australia.
FAU - Bell-Anderson, Kim S
AU  - Bell-Anderson KS
AD  - School of Molecular Bioscience; University of Sydney; Sydney, NSW Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140108
PL  - United States
TA  - Adipocyte
JT  - Adipocyte
JID - 101567863
PMC - PMC3979885
OTO - NOTNLM
OT  - adipokines
OT  - adipolin
OT  - adiponectin
OT  - diabetes
OT  - insulin resistance
OT  - leptin
OT  - obesity
EDAT- 2014/04/11 06:00
MHDA- 2014/04/11 06:01
PMCR- 2015/04/01
CRDT- 2014/04/11 06:00
PHST- 2013/10/14 00:00 [received]
PHST- 2013/12/11 00:00 [revised]
PHST- 2013/12/16 00:00 [accepted]
PHST- 2014/04/11 06:00 [entrez]
PHST- 2014/04/11 06:00 [pubmed]
PHST- 2014/04/11 06:01 [medline]
PHST- 2015/04/01 00:00 [pmc-release]
AID - 2013ADIPOCYTE134R4 [pii]
AID - 10.4161/adip.27552 [doi]
PST - ppublish
SO  - Adipocyte. 2014 Apr 1;3(2):88-96. doi: 10.4161/adip.27552. Epub 2014 Jan 8.