PMID- 24719843
OWN - NLM
STAT- MEDLINE
DCOM- 20141230
LR  - 20211021
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2014
DP  - 2014
TI  - Preparation of cylinder-shaped porous sponges of poly(L-lactic acid), 
      poly(DL-lactic-co-glycolic acid), and poly(epsilon-caprolactone).
PG  - 106082
LID - 10.1155/2014/106082 [doi]
LID - 106082
AB  - Design of mechanical skeletons of biodegradable synthetic polymers such as 
      poly(L-lactic acid) (PLLA), poly(DL-lactic-co-glycolic acid) (PLGA), and 
      poly(epsilon-caprolactone) (PCL) is important in the construction of the hybrid 
      scaffolds of biodegradable synthetic polymers and naturally derived polymers such 
      as collagen. In this study, cylinder-shaped PLLA, PLGA, and PCL sponges were 
      prepared by the porogen leaching method using a cylinder model. The effects of 
      polymer type, polymer fraction, cylinder height, pore size, and porosity on the 
      mechanical properties of the cylinder-shape sponges were investigated. SEM 
      observation showed that these cylinder-shaped sponges had evenly distributed bulk 
      pore structures and the wall surfaces were less porous with a smaller pore size 
      than the wall bulk pore structures. The porosity and pore size of the sponges 
      could be controlled by the ratio and size of the porogen materials. The PLGA 
      sponges showed superior mechanical properties than those of the PLLA and PCL 
      sponges. Higher porosity resulted in an inferior mechanical strength. The pore 
      size and sponge height also affected the mechanical properties. The results 
      indicate that cylinder-shaped sponges can be tethered by choosing the appropriate 
      polymers, size and ratio of porogen materials and dimension of sponges based on 
      the purpose of the application.
FAU - He, Xiaoming
AU  - He X
AD  - Tissue Regeneration Materials Unit, International Center for Materials 
      Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, 
      Tsukuba, Ibaraki 305-0044, Japan.
FAU - Kawazoe, Naoki
AU  - Kawazoe N
AD  - Tissue Regeneration Materials Unit, International Center for Materials 
      Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, 
      Tsukuba, Ibaraki 305-0044, Japan.
FAU - Chen, Guoping
AU  - Chen G
AD  - Tissue Regeneration Materials Unit, International Center for Materials 
      Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, 
      Tsukuba, Ibaraki 305-0044, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140227
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Biodegradable Plastics)
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 24980-41-4 (polycaprolactone)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 459TN2L5F5 (poly(lactide))
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Biodegradable Plastics/chemical synthesis/chemistry
MH  - Collagen/chemistry
MH  - Humans
MH  - Lactic Acid/chemical synthesis/*chemistry
MH  - Polyesters/chemical synthesis/*chemistry
MH  - Polyglycolic Acid/chemical synthesis/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/chemical synthesis/*chemistry
MH  - Porosity
MH  - *Tissue Engineering
PMC - PMC3955664
EDAT- 2014/04/11 06:00
MHDA- 2014/12/31 06:00
PMCR- 2014/02/27
CRDT- 2014/04/11 06:00
PHST- 2013/12/13 00:00 [received]
PHST- 2014/01/17 00:00 [accepted]
PHST- 2014/04/11 06:00 [entrez]
PHST- 2014/04/11 06:00 [pubmed]
PHST- 2014/12/31 06:00 [medline]
PHST- 2014/02/27 00:00 [pmc-release]
AID - 10.1155/2014/106082 [doi]
PST - ppublish
SO  - Biomed Res Int. 2014;2014:106082. doi: 10.1155/2014/106082. Epub 2014 Feb 27.