PMID- 24720253
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 1365-2559 (Electronic)
IS  - 0309-0167 (Linking)
DP  - 2013 Dec 3
TI  - Oestrogen receptor-beta as a potential target for treatment in advanced 
      colorectal cancer: a pilot study.
LID - 10.1111/his.12340 [doi]
AB  - AIMS: Oestrogen receptor-beta (ER-beta) is expressed in colorectal cancer. 
      Theoretically, ER-beta stimulation could slow down tumour proliferation, and this is 
      supported by preclinical research data. While preparing a Phase II trial for 
      advanced colorectal cancer patients we performed a pilot study with three 
      questions: (i) in what percentage of patients do metastases display strong ER-beta1 
      expression; (ii) is there any concordance in expression between primary tumours 
      and metastases; and (iii) is the immunohistochemical (IHC) scoring procedure 
      reproducible? METHODS AND RESULTS: Thirty patients were selected, 15 with 
      locoregional lymph node metastases and 15 with either synchronous or metachronous 
      hepatic metastases. All primary tumours and metastases were analysed for 
      immunohistochemical ER-beta1 expression according to a predefined scoring system. 
      The scoring was performed independently by two pathologists in order to calculate 
      the weighted kappa value. Strong ER-beta1 expression was found in four of 15 hepatic 
      metastases and four of 15 lymph node metastases. In 15 of 30 patients, the level 
      of ER-beta1 expression in the metastasis was concordant with that observed in the 
      primary tumour. Weighted kappa values of IHC ER-beta1 expression were satisfactory. 
      CONCLUSIONS: In twenty-five per cent of patients there was strong ER-beta1 
      expression in metastases, biopsy of which will be considered mandatory for trial 
      inclusion.
CI  - (c) 2013 John Wiley & Sons Ltd.
FAU - van Halteren, Henk
AU  - van Halteren H
AD  - Department of Internal Medicine, Admiraal de Ruijter Hospital, Goes, the 
      Netherlands.
FAU - Mulder, Dries
AU  - Mulder D
FAU - Ruijter, Emiel
AU  - Ruijter E
LA  - eng
PT  - Journal Article
DEP - 20131203
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
OTO - NOTNLM
OT  - colorectal cancer
OT  - metastasis
OT  - oestrogen receptor-beta
OT  - targeted therapy
EDAT- 2014/04/12 06:00
MHDA- 2014/04/12 06:00
CRDT- 2014/04/12 06:00
PHST- 2013/09/18 00:00 [received]
PHST- 2013/11/30 00:00 [accepted]
PHST- 2014/04/12 06:00 [entrez]
PHST- 2014/04/12 06:00 [pubmed]
PHST- 2014/04/12 06:00 [medline]
AID - 10.1111/his.12340 [doi]
PST - aheadofprint
SO  - Histopathology. 2013 Dec 3. doi: 10.1111/his.12340.