PMID- 24720638
OWN - NLM
STAT- MEDLINE
DCOM- 20140922
LR  - 20211021
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Print)
IS  - 1044-5498 (Linking)
VI  - 33
IP  - 8
DP  - 2014 Aug
TI  - Correlations of MCP-1 -2518A>G polymorphism and serum levels with cerebral 
      infarction risk: a meta-analysis.
PG  - 522-30
LID - 10.1089/dna.2013.2263 [doi]
AB  - This meta-analysis was performed to evaluate the relationships between the 
      monocyte chemoattractant protein-1 (MCP-1) -2518A>G (rs1024611 A>G) polymorphism 
      and its serum levels, and the risk of cerebral infarction. The PubMed, CISCOM, 
      CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM 
      databases were searched for relevant articles published before October 1st, 2013 
      without language restrictions. Meta-analysis was conducted using the STATA 12.0 
      software. Crude odds ratios (ORs) or standardized mean difference (SMD) with 
      their 95% confidence intervals (95% CIs) were calculated. Twelve case-control 
      studies that met all the inclusion criteria were included in this meta-analysis. 
      A total of 1272 patients with cerebral infarction and 1210 healthy control 
      subjects were involved in this meta-analysis. Our meta-analysis results reveal 
      that the MCP-1 -2518A>G polymorphism might increase the risk of cerebral 
      infarction (A allele vs. G allele: OR=1.37, 95% CI: 1.18-1.60, p<0.001; GA+AA vs. 
      GG: OR=1.33, 95% CI: 1.09-1.62, p=0.005; respectively). Furthermore, cerebral 
      infarction patients had higher levels of serum MCP-1 than did healthy control 
      subjects (SMD=2.96, 95% CI: 2.00-3.92, p<0.001). Statistical analysis revealed no 
      evidence of publication bias in this meta-analysis (all p>0.05). Our findings 
      indicate that the MCP-1 -2518A>G polymorphism and serum MCP-1 levels may 
      contribute to the development of cerebral infarction. Thus, the MCP-1 -2518A>G 
      polymorphism and serum MCP-1 levels could be potential biomarkers for the early 
      detection of cerebral infarction.
FAU - Gao, Hong-Hua
AU  - Gao HH
AD  - Department of Neurology, The Fourth Affiliated Hospital of China Medical 
      University , Shenyang, People's Republic of China .
FAU - Gao, Lian-Bo
AU  - Gao LB
FAU - Wen, Jia-Mei
AU  - Wen JM
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20140410
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
EIN - DNA Cell Biol. 2015 Jul;34(7):504. PMID: 26083152
MH  - Case-Control Studies
MH  - Cerebral Infarction/blood/*genetics
MH  - Chemokine CCL2/blood/*genetics
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Risk
PMC - PMC4117263
EDAT- 2014/04/12 06:00
MHDA- 2014/09/23 06:00
PMCR- 2015/08/01
CRDT- 2014/04/12 06:00
PHST- 2014/04/12 06:00 [entrez]
PHST- 2014/04/12 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - 10.1089/dna.2013.2263 [pii]
AID - 10.1089/dna.2013.2263 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2014 Aug;33(8):522-30. doi: 10.1089/dna.2013.2263. Epub 2014 Apr 
      10.